15例无抽搐电休克对认知功能和内分泌功能影响的研究

Effect of modified electroconvulsive therapy on cognition and endocrine hormone level

目的:探讨无抽搐电休克对认知功能及内分泌激素的影响。方法:在MECT治疗前后,完成事件相关电位(P300)和内分泌激素水平,比较治疗前后患者P300和内分泌激素的差异。结果:P2、N2、P3波幅在所有患者治疗前后的差异均有统计学意义。仅有T3在所有受试者中治疗后显著低于治疗前。结论:MECT能在某种程度上改善患者注意、思维、判断以及言语整合的能力且对内分泌激素影响不大。

Objective：To explore the influence of Modified Electroconvulsive Therapy（MECT） on cognition and Endocrine Hormone Levels（EHL）.Methods：Fifteen patients with schizophrenia or major depression were recruited in the current study.The P300 and EHL were examined in all subjects before treatment and after a 2-week treatment with MECT in those patients.Results： The wave amplitudes of P2,N2,P3 was significantly higher in posttreatment group than that of pretreatment.There was only T3 that was significant lower in posttreatment group than that of pretreatment.Conclusions： MECT can improve patient attention,thinking,judgments,and the ability to integrate speech and has little impact on the EHL of patient.