阿普唑仑联合奋乃静治疗24例酒精戒断综合征的对照研究

Alprazolam combined with perphenazine in the treatment of alcohol withdrawal syndrome-control study

目的:探讨阿普唑仑联合小剂量奋乃静治疗酒精戒断综合征的疗效。方法:48例存在酒精戒断综合征的患者随机分为阿普唑仑组(采用阿普唑仑联合奋乃静治疗)及氟哌啶醇组(氟哌啶醇治疗),每组各24例,采用酒精戒断综合征评定量表[1]、抑郁自评量表(SDS)评定疗效。结果:阿普唑仑组的酒精戒断综合征评定量表在治疗第3、57、天的评分均显著低于氟哌啶醇组,而抑郁自评量表(SDS)在第5、7天的评分也显著低于氟哌啶醇组。结论:阿普唑仑联合小剂量奋乃静治疗酒精戒断综合征的疗效确切安全。

Objective：To explore the alprazolam dose of perphenazine in the treatment combined with low alcohol withdrawal syndrome.Methods：48 patients with presence of alcohol withdrawal syndrome patients were randomly divided into groups of Alprazolam（Alprazolam combined with perphenazine in the treatment） and the haloperidol group（haloperidol treatment）,each of 24 patients with alcohol withdrawal syndrome rating scale[1],self-rating depression scale（SDS） assessed efficacy.Results： Alprazolam group of alcohol withdrawal syndrome rating scale in the treatment of the first 3,5,7-day scores were significantly lower than the haloperidol group,while the self-rating depression scale（SDS） in section 5,7-day rates are also significantly lower than the haloperidol group.Conclusions： Alprazolam combined with small dose of perphenazine in the treatment of alcohol withdrawal syndrome the exact security.