奖赏缺陷综合征研究进展
摘要
奖赏缺陷综合征（Reward Deficiency Syndrome）这一概念由Kenneth Blum于1995年提出，指由于基因异常等原因导致脑内奖赏系统内神经递质功能异常，最终导致维持大脑正常奖赏愉悦感的多巴胺功能低下（多巴胺释放、转运以及多巴胺受体可利用性异常等），引发一系列冲动性、强迫性以及成瘾性行为障碍综合征。
出处
《中国民康医学》
2011年第11期1385-1388,共4页
Medical Journal of Chinese People’s Health
参考文献41
-
1Blum K, Sheridan PJ, Wood RC, et al. Dopamine Dz receptor gene variants : association and linkage studies in impulsive - addictive - compulsive behavior [ J ]. Pharmacogenetics, 1995,5 ( 3 ) : 121 - 141.
-
2Bowirrat A, Oscar - Berman M. Relationship between dopaminergic neurotransmission, alcoholism, and Reward De? ciency Syndrome[JJ. Am J Med Genet B Neuropsychiatr Genet, 2005,132 (1):29-37.
-
3Blum K, Kozlowski GP. Ethanol and neuromodulator interactions: a cascade model of reward. Netherlands: VSP Press, 1990:131 - 149.
-
4Comings DE, Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders[ J ]. Prog Brain Res, 2000,126 ( 3 ) : 325 - 341.
-
5Xiao C, Zhang J, Krnjevi K, Ye JH : Effects of ethanol on mid - brain neurons: role of opioid receptors[ J]. Alcohol C|in Exp Res, 2007, 31 (7) :1106 - 1113.
-
6Blum K, Chen TJ, Meshkin B, Waite RL, Downs BW, Blum SH, Mengucci JF, Arcuri V, Braverman ER, Palomo T: Manipulation of cate - chol - O - methyl - transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS) , is dependent upon geue polymorphisms : a hypothesis. Med Hypotheses 2007,69 (5) : 1054 - 1060.
-
7Blum K, Braverman ER, Holder JM, et al. 2000. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors [ J]. J Psychoactive Drugs, 2000,32 (Suppl) : 111 - 112.
-
8Green AI, Zimmet SV, Strous RD, et al. Clozapine for comorbid substance use disorder and schizophrenia: dopatients with schizophrenia have a reward - deficiency syn - drome that can be ameliorated by clozapine? Harv Rev Psychiatry, 1999, 6(6) :287 -296.
-
9Rajita Sinha. Modeling stress and drug craving in the laboratory: implications for addiction treatment development[J]. Addict Biol, 2009,14(1) : 84 -98.
-
10Volkow ND, Wang GJ, Begleiter H, High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors [ J ]. Arch Gen Psychiatry, 2006,63 (9) :999 - 1008.
-
1Kirkpatrick B,Buchanan RN,杨权.分裂症缺陷综合征的神经基础[J].国外医学（精神病学分册）,1991,18(3):148-151.
-
2喻雪寒.缺陷综合征[J].国外医学（精神病学分册）,2003,30(4):218-220. 被引量：2
-
3李丹,陈长香,马素慧,赵雅宁,李淑杏.脑梗死患者执行功能障碍程度的危险因素研究[J].现代预防医学,2013,40(21):4057-4059. 被引量：5
-
4杨南竹,贠相华,周玉颖,吴玉秋,王宏艳.多奈哌齐治疗痴呆的系统评价[J].中风与神经疾病杂志,2014,31(2):158-160. 被引量：8
-
5山胁健盛,滕伟禹,陈谅.目前值得关注的危险因素、基因异常[J].日本医学介绍,2001,22(3):115-116.
-
6许家玉,高华,刘玉厚,刁俊荣,余西金.精神分裂症缺陷型、非缺陷型与阴、阳性分型关系的研究[J].中国民康医学,1999,0(2):3-5.
-
7李丹,邢琰,陈长香,郝习君,王静.脑梗死患者执行功能障碍程度的影响因素[J].中国老年学杂志,2014,34(24):7072-7073. 被引量：5
-
8王常欣.运动神经元病[J].健康博览,1996,0(10):12-12.
-
9郝勇,吴帅,朱萱,管阳太.单基因缺血性脑卒中[J].上海医学,2009,32(4):354-357.
-
10赵靖平.关注精神分裂症的阴性症状[J].心理与健康,2016,0(6):6-7.
