鲨螺硒胶囊毒理学研究

A study of toxicology for Shaluoxi Capsule

目的:观察鲨螺硒胶囊的急性和慢性毒性作用,为临床应用提供理论基础。方法:在24 h内给小鼠灌胃投服鲨螺硒胶囊2次,观察其急性毒性反应。给大白鼠灌胃投服鲨螺硒胶囊连续12周,观察其长期毒性反应。结果:小鼠急性毒性最大耐受量(MTD)实验,未见动物有异常反应,灌服的MTD为20 g/kg体重。大白鼠长期毒实验,其体重增长、血常规以及血液生化各项指标均在正常范围内,病理学组织检查未见异常。结论:鲨螺硒胶囊按拟定方案、剂量、途径和疗程使用应是安全的。

Objective： To observe the toxic effects of Shaluoxi Capsule.Methods： For observing acute toxicity,mice were administrated 2 doses/day of the capsules by ig.For observing chronic toxicity,the rats were administrated the capsules once a day for 12 weeks.Results： The maximum tolerated dose of the capsules in mice was 20 g/kg.In the experiment of chronic toxicity,after took the capsules for 12 weeks,the indexes of body weight growth,blood routine tests and blood chemical analysis were in normal ranges.The abnormal sign had not been found in pathological examination.Conclusion： The experimental results indicate that the Shaluoxi designed therapeutic scheme,administration route and dose are safe.