神经型钙黏附蛋白与恶性肿瘤的关系

Relationship between N-cadherin and malignant tumor

神经型钙黏附蛋白(N-cadherin)在上皮恶性肿瘤中表达上调,且与上皮-间质转换关系密切,N-cadherin高表达提示肿瘤的能动性和转移能力增强,在肿瘤的发生、浸润、转移、血管生成中起了重要作用。ADH-1作为N-cadherin抗体的一个全身性抗癌药,诱导靶细胞的凋亡,破坏肿瘤组织中的血管,通过破坏胞外N-cadherin间的黏附,改变N-cadherin和成纤维细胞生长因子受体(FGFR-1)间的关系,破坏FGFR-1,导致FGFR-1表达缺失,从而破坏肿瘤血管,抑制肿瘤的生长,为临床肿瘤的治疗提供了理论基础。

The expression of N-cadherin is upregulated in epithelial malignant tumor and is associated with epithelial to mesenchymal transition.The overexpression of N-cadherin expression has been shown to promote motility and invasion. N-cadherin plays an important role in the tumorigenesis, infiltration, metastasis and angiogenesis.ADH-1 as a systemic anticancer agent can induce apoptosis of the target cells and cause tumour vascular damage,which disrupt extracellular N-cadherin adhesion, altering the association of N-cadherin and FGFR-1, and destabilized FGFR-1 to induce the expression of FGFR-1 lost,and the result was that the tumour vascular was damaged and the growth of tumor was inhibited. It providing a theoretical basis for treatment of clinical oncology.