孟鲁司特钠治疗毛细支气管炎的临床疗效观察

Therapeutic effect of adjunctive therapy for bronchiolitis with montelukast sodium

目的探讨孟鲁司特钠治疗毛细支气管炎的临床疗效。方法将76例毛细支气管炎患儿随机分为两组:对照组给予抗病毒、止咳祛痰和布地奈德混悬液、复方异丙托溴胺溶液(可比特)雾化吸入,地塞米松静脉滴注等常规治疗;治疗组在对照组基础上加用孟鲁司特钠口服。观察两组治疗后临床疗效、症状、体征持续时间。结果治疗组总有效率(92.50%)高于对照组的总有效率(72.22%)(P<0.01)。治疗组气喘消失、哮鸣音消失、咳嗽消失时间均较对照组缩短(P<0.01)。结论孟鲁司特钠可明显提高毛细支气管炎的治疗效果,值得临床应用。

Objective To study the efficacy of montelukast sodium in adjunctive treatment for bronchiolitis.Methods A total of 76 patients with bronchiolitis were randomly divided into treatment group（n=40） and control group（n=36）.Patients in control group were treated by conventional drugs such as anti-virus drugs,drugs for relieving coughing and expectorant,budesonide,Combivente nebulizing inhalation and intravenous drip of Hexadecadrol（dexamethasone）.Patients in treatment group were additionally administrated with oral montelukast sodium based on foregoing conventional drugs.All patients in these two groups were observed for sustained duration of clinical symptoms and signs after treatment.Results The total effective rate in patients of treatment group was 92.50%,it was higher than the total effective rate of 72.22% in control group,and the difference between these two groups was significant（P0.01）.The duration for asthmatic remission and symptomatic relief in patients of treatment group was significantly shorter than that of patients in control group（P0.01）.Conclusion This study indicated that adjunctive therapy for bronchiolitis with montelukast sodium is more effective than conventional drug treatment.