曲唑酮治疗老年期抑郁症的研究

The effect of trazodone for the senile depression

目的探讨曲唑酮治疗老年期抑郁症的疗效。方法 60例符合诊断标准的老年期抑郁症患者随机分为曲唑酮组和文拉法辛组,疗程8周。采用汉密尔顿抑郁量表(HAMA),评定疗效。采用治疗中需处理的不良反应症状量表(TESS)评定安全性。结果在第1周末研究组(曲唑酮组)有效率为30.00%;对照组(文拉法辛组)有效率为10.00%。两组有效率有显著性差异(χ2=3.85、P<0.05)。治疗8周末研究组总有效率93.33%,对照组总有效率86.67%,两组总有效率无显著性差异(χ2=0.187、P>0.05),说明两者总体疗效相当。两组TESS评分在治疗后1、2、4及8周末差异均无统计学意义(P>0.05)。结论曲唑酮治疗老年期抑郁症起效快,安全性好,副作用少。

Objective To explore the effect of trazodone in treatment of senile depression patients.Methods 60 patients who met the International Classification of Diseases Tenth Edition（ICD-10） diagnostic criteria for senile depression were recruited,they were randomly assigned to venlafaxine group and trazodone group for 8 weeks treatment.Hamilton depression rating scale（HAMA）,was used to evaluate the effect.Treatment emergent symptoms scale（TESS） was used to evaluate the safety.Results After 1 week＇s treatment,the effective rate of the study group（trazodone group） was 30.00%,the control group（venlafaxine group） was 10.00%.The statistical difference was significant（χ2=3.85,P0.05）.After 8 weeks＇ treatment,the total effective rate of the study group was 93.33%,the control group was 86.67%.There were no significant difference（χ2=0.187,P0.05）.There were no signifiant differences between the two groups in the TESS score at the end of 1 week,2 weeks,4 weeks and 8 weeks.Conclusion Trazodone had the advantage of rapid onset,good safety and few side effects in the treatment of senile depression.