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兔动脉粥样硬化斑块的MR实验研究 被引量：2

MRI in detection of atherosclerotic plaque in rabbits:an experimental study
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摘要 目的应用MRI对兔动脉粥样硬化斑块进行成像。方法应用动脉内膜损伤和高胆固醇饮食建立兔动脉粥样硬化模型,采用多种序列对实验动物动脉血管进行成像,并与病理相对照。结果成功建立兔动脉粥样硬化模型;MR图像T1WI、T2WI、PDWI表现为兔动脉管壁增厚,斑块呈等信号、高信号或低信号,与病理切片检测结果符合率较高;MR能够发现动脉血管粥样硬化斑块,并可协助分析其成分。结论 MR可以检测兔动脉粥样硬化模型的斑块,亦可能对斑块定性分析有帮助。 Objective To study the feasibility of using MRI in detection of atherosclerotic plaque in rabbits.Methods Atherosclerosis was induced in 12 New Zealand white male rabbits（2～3kg） with aortic balloon endothelial injury followed by a high cholesterol（1.5%） diet for 16 weeks.T1WI,T2WI,PDWI and TOF sequences were performed by 1.5T MRI scanner.Results The atherosclerosis model was successfully established in rabbits.MR images showed thickening of aortal wall in atherosclerosis rabbits.The atherosclerotic plaques showed equal,higher or lower signal intensities which were accordant with the pathological findings.The atherosclerotic plaques were successfully detected by MR.Conclusion MR can be used for detection of the atherosclerosis plaque and may be help in the plaque analysis.
作者 李晓兵 徐晓 刘可夫 秦明明 程庆璋 王风 周大勇
机构地区 江苏省苏州市立医院本部
出处 《中国现代医药杂志》 2011年第6期43-45,共3页 Modern Medicine Journal of China
关键词 磁共振成像 动脉粥样硬化 斑块 Magnetic resonance imaging Arteriosclerosis Plaque
分类号 R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

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二级参考文献8

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同被引文献14

  • 1Roger V L, Go A S, Lloyd-Jones D M, et al. Heart disease and stroke statistics-2011 update: a report from the american heart association[J]. Circulation, 2011, 123(4) :e18-e209.
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  • 7马占龙.MRI评价兔动脉粥样硬化模犁[J].中国医学影像技术.2010,26(1):1-3.
  • 8武兆忠,刘敏,李志铭,张昊,林伟,王金玉,李园.纳米氧化铁颗粒表征分析及其对体外标记肿瘤细胞磁信号变化的影响[J].中国组织工程研究与临床康复,2010,14(8):1402-1407. 被引量：7
  • 9李勇刚,朱默,戴颖钰,陈剑华,倪健坤,郭亮.USPIO增强MRI检测兔动脉粥样硬化斑块的实验研究[J].中国医学计算机成像杂志,2010,16(2):152-156. 被引量：6
  • 10陈骏,贾振宇,马占龙,聂芳,麦筱莉,王圆圆,滕皋军.7T Micro-MRI活体观察内皮祖细胞促进小鼠颈动脉损伤后的修复[J].实用放射学杂志,2010,26(7):1025-1029. 被引量：2

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中国现代医药杂志
2011年 第6期

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