系统性红斑狼疮患者的抑郁情绪与疾病因素的关联性研究进展

Advances in studies on depression and its disease related factors of patients with systemic lupus erythematosus

系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种累及多系统、多器官并有多种自身抗体出现的自身免疫性疾病。多数SLE患者存在抑郁情绪。抑郁与患者的疾病活动、累积损害、激素用量以及抗核糖体P蛋白抗体(anti-ribosomal P protein antibodies,anti-P)之间的相关性研究结果各不相同;抑郁与患者的睡眠质量、疲乏症状、纤维肌痛和偏头痛、认知功能、焦虑以及治疗依从性均有关联。

Systemic lupus erythematosus（SLE） is a chronic autoimmune disease characterized by a diverse array of autoantibody production that affects multiple systems and organs.Most of patients are in depression mood.The relationship between depression and disease activity,cumulative damage,dosage of glucocorticoid and anti-ribosomal P protein antibodies（anti-P） were still controversial.Depression was correlated with sleep quality,fatigue,fibromyalgia,migraine,cognitive impairment,anxiety and patients＇ medication compliance.