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血清胱抑素C测定在临床中的研究进展(综述) 被引量：1

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摘要 血清胱抑素C(Cystatin C)作为检测肾功能的一种新的内源性标志物,近年来受到临床上的高度重视[1]。它与目前临床上常用的反映肾小球滤过功能(GFR)的指标,如菊粉清除率,同位素标记物清除率,内生肌酐清除率(Ccr),血尿素氮(BUN)和血清肌酐(SCr)等相比,具有独特的优点,稳定、可靠、方便。循环中的胱抑素C仅经肾小球滤过而被清除,是一种反映肾小球滤过率变化的理想的内源性标志物[2]。本文简要介绍CysC的特点,重点介绍其在临床中的研究进展。
作者 李桂珍 陈雪雯
机构地区 天津市中医药研究院附属医院
出处 《中国城乡企业卫生》 2011年第3期58-60,共3页 Chinese Journal of Urban and Rural Enterprise Hygiene
关键词 胱抑素C 临床应用 肾小球滤过率
分类号 R692 [医药卫生—泌尿科学]
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参考文献21

  • 1Grubb AO. Cys C-properties and use as diagnostic marker. Adv Clin Chm,2000,35:63-99.
  • 2Grubb A, Simonsen O, Sffeit G, et al. Serum concentration of cystatinC, factorD and β mincroglbulin as ameasure of glomerular filtration rate[J]. ActaMeed Scand, 2006, 218: 499.
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  • 7Grawford FC, Freman M J, Schinka JA, et al. Apolymorphismin cyatatin C geneisnovel risk factor for late-onset Alzheimers diaease. Neurology, 2000, 55(2): 763-768.
  • 8刘建,杭永伦,侯静,李友芸.胱抑素与老年肌酐正常肾损害患者肾小球滤过率的相关性研究[J].中国实用内科杂志,2005,25(8):725-726. 被引量：14
  • 9罗长青,王玉梅,邓安国,熊洁,付玲.测定血清Cystatin C浓度判断肾小球滤过率的临床意义[J].临床内科杂志,2003,20(3):154-155. 被引量：50
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二级参考文献27

  • 1方一卿,马骏,沈汉超,鲁盈.血清胱抑素C评价慢性肾脏病患者早期肾损害的临床研究[J].中国中西医结合肾病杂志,2007,8(3):145-148. 被引量：58
  • 2Tan GD, Lewis AV, James TJ, et al. Clinical usefulness of Cystain C for the estimation of glomerular mate in type Ⅰ diabetes [ J ]. Diabetes Care, 2002,25 ( 11 ) :2004.
  • 3Mendiluce A, Bustamante J, Martin D, et al . Cystatin C as. a marker for renal function in kidney transplant patients [ J ]. Transplant Pree, 2005,37 (9) : 3844.
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  • 7[4]Newman DJ,Thakkar H,Edwards RG,et al.Serum Cystatin C measured by automated immunoassay:A more sensitive marker of changes in GFR than serum creatinine.Kidney Int,1995,47:312-318.
  • 8[5]Elisabeth Coll,Albert Botey, Luisa Alvarez, et al. Serum Cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment.American Journal of Kidney Disease,2000,36:29-34.
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  • 10Schuck O,Teplan V,Sibova J,et al.Predicting the glomerular filtration rate from serum creatinine,serum cystatin C and the Cockcroft and gault formula with regard to drug dosage adjustment.Int J Clin Pharmacol Ther,2004,42(2):93-97.

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中国城乡企业卫生
2011年 第3期

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