广州地区住院新生儿轮状病毒感染的季节性及其临床分析

Clinic and epidemiology of neonatal rotavirus infection?An,investigation in 244 hospital neonates in Guangzhou area.

从１９９０ 年１０ 月至１９９２ 年９ 月，分别在轮状病毒腹泻的流行季节（每年１０ 月至次年２ 月） 和非流行季节（ 每年３月至９ 月） 收集广州地区２４４ 例住院新生儿粪便６４５ 份，用核酸电泳（ＰＡＧＥ）技术检测轮状病毒（ＨＲＶ）ＲＮＡ。结果显示：新生儿ＨＲＶ感染很普遍，感染率高达６５．１６％ ，临床表现为轻型腹泻或无症状。流行季节与非流行季节的感染率分别为７７．３１％和５３．６３％ ，二者感染后发病和无症状的先例亦不相同，流行季节发病率明显高于非流行季节。表明新生儿ＨＲＶ 感染虽然全年可发生，且存在无症状感染这一特异现象，但与婴幼儿类似，亦有秋冬季流行和发病的趋势。提示新生儿的ＨＲＶ 传染源主要来自生后环境。在婴幼儿ＨＲＶ 腹泻的流行季节应重点加强对新生儿的保护。

In order to find out clinical and epidemiologic fentures of human rotavirus (HRV,group A inrection of neonates in Guangzhou area,an investigation was carried out.244 hospitalized newborns were registered from Oct 1990 to Sep 1992,their faces being collected for detecting HRV RNA by polyacrylamide gel electrophoresis (PAGE) and symptoms and signs of diarrhea were recorded.Todally 645 fecal samples were examined.Results demonstrate that 65.16% (159/244) neonates were infected with HRV presenting asymptomatic (77/159) or mild diarrhoea (82/159),Comparison of infection rate between different seasons showed that neonatal HRV infection is more frequent in autumn and winter which is similar to that of infants and toaddlers.We conclude that pretection should be emphasized on neonates during the epidemiological seaeons of HRV.