雌激素替代治疗对绝经后特发性流出道室性心律失常的影响

Effect of estrogen replacement therapy on idiopathic outflow tract ventricular arrhythmias in postmenopausal women

目的:探讨性激素水平与绝经后女性特发性室性心律失常(IOTVA)的关系,并观察雌激素替代治疗对其影响。方法:检测绝经后女性正常组和IOTVA患者组血清性激素水平及室性心律失常数目;观察IOTVA组给予雌激素替代治疗后的效果。结果:IOTVA组雌激素水平较正常绝经后女性相比显著降低(8.4±3.4 vs 36.9±12.8 pg/mL,P<0.01)。绝经后女性IOTVA患者室性心律失常计数较正常对照组显著升高(10 171±6 091 vs 209±468个/24 h,P<0.01)。雌激素替代治疗后,IOTVA组患者室性心律失常计数较治疗前显著减少(3 958±1 972 vs 10 171±6 091个/24 h,P<0.01)。结论:本研究显示绝经后女性IOTVA患者雌激素水平较正常绝经后女性降低,而且雌激素替代治疗可以有效抑制IOTVA发生。

Objective： To investigate the relationship between hormone levels and the development of idiopathic outflow tract ventricular arrhythmias（IOTVA） as well as the effect of oestrogen replacement therapy on IOTVA in postmenopausal female patients.Methods： Plasma hormone concentrations and ventricular arrhythmia counts were estimated in both postmenopausal patients with IOTVA（IOTVA group） and healthy postmenopausal women（control group）.Therapeutic effects of IOTVA group that was treated with oestrogen replacement therapy were observed.Results： The concentration of oestradiol of IOTVA group was significantly lower than that in control group（8.4±3.4 pg/mL vs.36.9±12.8 pg/mL,P0.01）;while the ventricular arrhythmia counts in IOTVA group was significantly higher than that in the controls（10,171±6091 counts/24 h vs.209±468 counts/24 h,P0.01）.After 3 months of treatment by oestrogen replacement therapy,the ventricular arrhythmia counts of the IOTVA group significantly decreased（3958±1972 vs.10,171±6091 counts/24 h,P0.001）.Conclusions： This study shows that the concentration of oestradiol is lower in postmenopausal patients with IOTVA comparing with their healthy coutparts,and oestrogen replacement therapy can inhibit development of IOTVA effectively.