摘要
目的:探讨性激素水平与绝经后女性特发性室性心律失常(IOTVA)的关系,并观察雌激素替代治疗对其影响。方法:检测绝经后女性正常组和IOTVA患者组血清性激素水平及室性心律失常数目;观察IOTVA组给予雌激素替代治疗后的效果。结果:IOTVA组雌激素水平较正常绝经后女性相比显著降低(8.4±3.4 vs 36.9±12.8 pg/mL,P<0.01)。绝经后女性IOTVA患者室性心律失常计数较正常对照组显著升高(10 171±6 091 vs 209±468个/24 h,P<0.01)。雌激素替代治疗后,IOTVA组患者室性心律失常计数较治疗前显著减少(3 958±1 972 vs 10 171±6 091个/24 h,P<0.01)。结论:本研究显示绝经后女性IOTVA患者雌激素水平较正常绝经后女性降低,而且雌激素替代治疗可以有效抑制IOTVA发生。
Objective: To investigate the relationship between hormone levels and the development of idiopathic outflow tract ventricular arrhythmias(IOTVA) as well as the effect of oestrogen replacement therapy on IOTVA in postmenopausal female patients.Methods: Plasma hormone concentrations and ventricular arrhythmia counts were estimated in both postmenopausal patients with IOTVA(IOTVA group) and healthy postmenopausal women(control group).Therapeutic effects of IOTVA group that was treated with oestrogen replacement therapy were observed.Results: The concentration of oestradiol of IOTVA group was significantly lower than that in control group(8.4±3.4 pg/mL vs.36.9±12.8 pg/mL,P0.01);while the ventricular arrhythmia counts in IOTVA group was significantly higher than that in the controls(10,171±6091 counts/24 h vs.209±468 counts/24 h,P0.01).After 3 months of treatment by oestrogen replacement therapy,the ventricular arrhythmia counts of the IOTVA group significantly decreased(3958±1972 vs.10,171±6091 counts/24 h,P0.001).Conclusions: This study shows that the concentration of oestradiol is lower in postmenopausal patients with IOTVA comparing with their healthy coutparts,and oestrogen replacement therapy can inhibit development of IOTVA effectively.
出处
《海南医学院学报》
CAS
2011年第6期750-752,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110185)~~
关键词
性激素
雌激素替代治疗
特发性室性心律失常
绝经后妇女
Hormones
Estrogen Replacement therapy
Idiopathic ventricular arrhythmias
Postmenopausal women