干细胞植入缺血大脑后功能研究进展

Progress in Stem Cell Implantation for Ischemic Brain Diseases

目前,干细胞移植在多个中枢神经系统疾病的研究和临床应用中取得突破性进展。其中,干细胞移植治疗脑缺血疾病是细胞移植治疗研究中最活跃的领域。但是,移植细胞是否具有神经元的功能及细胞移植治疗的机制目前存在很多争议。本文就干细胞移植治疗缺血性脑疾病后移植细胞的功能和治疗缺血性脑疾病机制的可能途径的研究情况作一综述。

The ischemic brain disease is one of the most common and severe diseases of the central nervous system. Nowadays, stem cell therapy, as a novel approach to treat these diseases, attracts great interest in both basic and clinic research. However, the mechanisms of the implanted stem cells functioning in the host remain to be determined. There are debates on questions like whether the stem cells display expected activities after transplantation, or whether paraerine pathway plays the major role. This review summarizes the progress in the recent research on the functions of the implanted stem cells after surgery and the possible mechanisms underlying this novel therapy.