大骨节病区与非病区儿童发中39种元素含量及Logistic分析

Logistic analysis and content of 39 elements in hair of children between Kashin Beck diseased areas and non Kashin Beck disease areas

目的 测定大骨节病（Ｋａｓｈｉｎ－Ｂｅｃｋ Ｄｉｓｅａｓｅ，ＫＢＤ）区与非病区儿童发中３９ 种元素的含量，用Ｌｏｇｉｓｔｉｃ 统计分析，以探讨硒等化学元素与ＫＢＤ 的关系。方法 采用病例对照研究，用ＩＣＰ－ＭＳ法检测ＫＢＤ 病区与非病区６～１４ 岁５ 个组１５０ 名男童发中３９ 种元素含量。结果 ＫＢＤ区儿童发硒、硼、碘显著低于非病区，而镁、铁、锰、钴、钒、锂含量依ＫＢＤ 患儿、病区健康儿童、非病区健康儿童递减。病区铝、镍、钍显著高于非病区；Ｌｏｇｉｓｔｉｃ 回归筛选出钙、钠、锗、铜、铁、硼、锂、铬、硒、锑、铅、锡１２ 种与ＫＢＤ 患病可能有关的元素。结论 除发硒含量低之外，ＫＢＤ有多种营养元素和毒性元素的失衡。

Objective Logistic analysis and content of 39 elements in hair of children between Kashin Beck Diseased(KBD) areas and non KBD areas were investigated in this paper in order to clear the relationship between chemical elements such as Se and KBD.Methods 150 children,aged 6~14 years old,males,in KBD areas and non KBD areas were divided into 5 groups.Contents of 39 elements in hair were assayed by ICP MS.Results Contents of Se,B,I in hair of children in KBD areas was significantly lower than that in non KBD areas but Mg,Fe,Mn,Co,V and Li declined following children with KBD,health in KBD areas and haelth in non KBD areas.Logistic regression were screened out 12 elements in hair related to KBD as follows:Ca,Na,Cu,Fe,B,Li,Cr,Se,Sb,Pb,Sn and Ge.Conclusions Several nutrient and toxic elements for human body besides Se were imbalance in hair of KBD children. [