原发性肝癌患者射频消融前后外周血T淋巴细胞绝对值变化的临床意义

The changes of the absolute T lymphocyte counts in paitents with primary hepatocellular carcinoma treated with radiofrequency ablation

目的观察射频消融治疗对肝癌患者外周血细胞T淋巴细胞计数的影响,探讨射频消融治疗对机体免疫功能的影响。方法随机选取30例行肝癌射频消融治疗的患者,分别于射频消融治疗前1d、治疗后14d和28d检查外周血CD4+、CD8+、CD3+、CD4+/CD8+比值,观察射频消融前后水平变化。结果 RFA后14dCD4+为36.48±10.21,CD8+为24.58±11.08;28dCD4+为37.10±10.86,CD8+为23.69±11.47,与术前CD4+(27.58±9.53)、CD8+(31.25±10.32)比较均有显著性差异,P<0.05。结论 RFA治疗后患者免疫功能得到显著改善,可能对肝癌患者的预后起到重要作用。

Objective To discuss the influence of radiofrequency ablation（RFA） on immunity function of patient with liver cancer.Methods Thirty liver cancer patients were treated by RFA,the changes of CD4＋ count,CD8＋ count,CD4＋/CD8＋ value of peripheral blood were respectively observed at day 1 before RFA,day 14 and 28 after RFA.Results CD4＋ count increased obviously at week 2 and week 4 after RFA,while CD8＋ value decreased obviously.Conclusions The immune function of patient was significantly improved in short-term after RFA.And it maybe improve the prognosis of patient with liver cancer.