奥曲肽治疗重症急性胰腺炎的疗效分析

THE ROLE OF OCTREOTIDE IN THE TREATMENT OF SEVERE ACUTE PANCREATITIS

为探讨奥曲肽对重症急性胰腺炎（ｓｅｖｅｒｅ ａｃｕｔｅ ｐａｎｃｒｅａｔｉｔｉｓ ，ＳＡＰ） 的治疗作用，对７６ 例ＳＡＰ 患者进行了前瞻性研究。除传统治疗外，加用奥曲肽。结果： 治疗组腹痛及压痛缓解、外周血白细胞计数、血淀粉酶恢复正常、腹水消失及治愈时间均明显短于对照组； 并发症发生率及手术率亦以治疗组为低。本结果提示早期应用奥曲肽对改善ＳＡＰ 症状有肯定的作用。其机理除直接或间接抑制胰腺的外分泌和胆汁分泌，松驰Ｏｄｄｉ 括约肌，减少胆汁返流入胰管外，可能还与改善胰腺组织的充血、水肿和减轻胰腺的损伤有关。

To evaluate the role of octreotide in the treatment of severe acute pancreatitis (SAP). Seventy six patients were divided into two groups (octreotide group, n =38, control group, n =38). All patients were treated by the same conservative regime. The octreotide group received octreotide. Results: The abdominal symptoms and signs, WBC count, serum amylase level, and volume of ascites were more effective controlled, with fewer complications occurred in octreotide group. Conclusion: Octreotide has a beneficial effect on the treatment of SAP, but the mechanism will be further investigated.