原发性胆囊癌患者红细胞变形性及其免疫粘附肿瘤细胞能力的研究

EXPERIMENTAL STUDY ON THE DEFORMATION OF RBC AND THE ABILIATY OF IMMUNE ADHESION OF RBC TO TUMOR CELL IN PATIENTS WITH PRIMARY GALLBLADDER CARCINOMA

研究、比较原发性胆囊癌（ｐｒｉｍ ａｒｙ ｇａｌｌｂｌａｄｄｅｒ ｃａｒｃｉｎｏ ｍａ ，ＰＧＣ） 患者红细胞变形性及其免疫粘附肿瘤细胞的能力，采用ＢＬ８８Ｂ 型激光衍射红细胞变形仪及肿瘤细胞血凝法，检测了２７ 例原发性胆囊癌患者红细胞变形指数及肿瘤红细胞血凝滴度阳性率与血清中调节因子的变化，并与正常对照组２０ 例相比较。结果： 原发性胆囊癌组红细胞变形指数明显低于正常对照组（ Ｐ＜ ０ ．００１） ，且红细胞免疫促进因子低于正常对照组，而红细胞免疫抑制因子高于正常对照组（ Ｐ＜ ０ ．０５） 。由此表明，原发性胆囊癌患者的红细胞免疫功能减低与血清中调节因子的变化密切相关。

To study the red cell′s deformation and the immune adhesion functions to tumor cell in patients with primary gallbladder carcinoma (PGC), twenty seven patients with PGC and twenty normal persons were investigated by means of BL 88 B type laser diffraction RBC deformation instrument and agglutinate method of tumor cell. The result showed that the RBC deformation index was lower in patients with PGC than that in the normal persons ( P <0.01). Also was the enhance factor of RBC immune adherent functions lower than that in the normal persons. While the inhibitory factor was higher than that in the normal persons. The result suggests that the decrease of RBC immune function be related with change of serum modulating factors in patient with PGC.