浸润性乳腺癌中c-erbB-2、nm23、PCNA产物检测及其预后价值

Prognostic significance of c erbB 2, nm23 and PCNA expression in invasive breast cancer

目的 探讨乳腺癌组织中 c- erb B- 2、nm2 3、PCNA蛋白与预后的关系。方法 对 72例浸润性乳腺癌组织进行 c- erb B- 2、m2 3及 PCNA产物的免疫组化检测。结果 c- erb B- 2、nm2 3及 PCNA的阳性率分别为 5 0 .0 %、 3 3 .3 %、90 .3 %。c- erb B- 2的表达与肿瘤大小及腋淋巴结转移呈正相关 ,与病人术后生存年限呈负相关 ;nm 2 3的表达在淋巴结无转移组明显高于有转移组 ,并与患者的术后生存年限有关 ,但与肿瘤大小无关 ;PCNA的表达与肿瘤大小明显正相关 ,与病人术后生存年限呈负相关 ,而与淋巴结转移情况无关。结论 nm2 3表达是乳腺癌病人预后良好的指标 ,而 c- erb B- 2及 PCNA的高表达则是肿瘤生长旺盛、易发生转移。

Objective Exploring the relation of cerbB 2、nm23、PCNA protein to prognosis in the breast cancer tissue.Methods\ Expression of c erbB 2,nm23 and PCNA in 72 cases of invasive breast cancer were examined by immunohistochemistry method Result results showed that the positive rates of c erbB 2,nm23 and PCNA protein in breast cancer were 50 0%,33 3% and 90 3%,respectively The expression of c erbB 2 was positively related to tumor size and axillary lymphnode metastasis,while negatively related to survival Nm23 expression was negatively related to axillary lymph node metastasis and positively related to survival,but had no relation to tumor size Higher PCNA expression was significant positively related to bigger tumor size and shorter living time,but not related to axillary lymph node metastasis Conclusions\ nm23 expression was related to better prognosis in breast cancer On the contrary,c erbB 2 and higher PCNA expressions were associated with malignant biological behavior and poor prognosis