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阴道镜联合HPV-DNA检测对宫颈不典型鳞状细胞的诊断价值 被引量:5

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摘要 目的评价宫颈细胞学检查、人乳头瘤病毒(HPV)-DNA检测联合阴道镜检查对子宫颈病变的诊断价值,探讨性质未定的不典型鳞状细胞(ASCUS)的临床处理方法。方法对经宫颈脱落细胞检查学诊断为ASCUS的90例患者行人HPV检测及阴道镜下多点活检。结果 90例ASCUS患者中,宫颈上皮内瘤变(CIN)及宫颈癌的发生率为31.11%(28/90),HPV阳性率为43.33%(39/90)。高危HPV阳性组CIN以上检出率为51.28%(20/39),HPV阴性组中CIN以上检出率为15.69%(8/51)。高危HPV阳性患者中以高危HPV16、HPV52、HPV58、HPV18、HPV33最多见。结论应加强对ASCUS患者的重视,尤其是合并高危HPV感染的患者,液基细胞学检查、HPV-DNA检测联合阴道镜检查能提高宫颈病变的检出率。
出处 《苏州大学学报(医学版)》 CAS 北大核心 2011年第2期336-337,共2页 Suzhou University Journal of Medical Science
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参考文献8

  • 1苏涛,章桂红,程利南.液基薄层细胞学技术在宫颈病变筛查中的应用及评价[J].国外医学(妇产科学分册),2004,31(4):252-255. 被引量:112
  • 2Jones HW. Clinical treatment of women with atypical squa- mous cell of undetermined significance or atypical glandular cells of ndetermined significance cervical cytology [ J ]. Clini Obsetet Gyneco1,2000,43 (2) : 381 - 393.
  • 3Zur Hausen H. Papillomavirus and cancer from basic stud- ies to clinical applications [ J ]. Nat Rev Cancer, 2002,2 (5) : 342 - 350.
  • 4Koss IG. Human papillomavirus testing as screening tool for cervical cancer [ J ]. JAMA,2000,283 ( 19 ) : 2525 - 2526.
  • 5王远菊,张洪文.TGF-β与HPV及宫颈癌的关系研究[J].中国误诊学杂志,2005,5(1):33-35. 被引量:10
  • 6张志胜.阴道镜图谱[M].北京:人民卫生出版社,2008:5.
  • 7Olaniya OB. Validity colposcopy in the diagnosis of early cervical neoplasia a review[J].Afr J Reprod Health ,2002, 6(3) :59 -69.
  • 8任青玲,卢苏,周云,陈琳.阴道镜检查850例宫颈癌诊断分析[J].华中医学杂志,2004,28(6):365-366. 被引量:6

二级参考文献41

  • 1El-sherif AM, Seth R,Tighe D J, et al. Decreased synthesis and expression of HPV 16 positive cervical precancer:a study by microdissection quantitative RT-PCR and immunocytochemistry[J ].J Pathol, 2000,192 (4) : 494-501.
  • 2Hazelbag S,Fleuren GJ,Baelde J J, et al. Cytokine profile of cervical cancer cells [J]. Gynecol Oncol. 2001 ,Nov, 83(2) : 235-243.
  • 3Farley U, Fray K, Nycun L, et al. Endocervical canceris assoliated with an increase in the ligands and receptors for transforming growth-beta and a contrasting decrease in PIT(Kipl)[J].Gynecol oncol,2000,78(21)zl13-122.
  • 4Tartour E,Gey A,. Sastre Garau X, et al. prognostic value of intratumoral interferon gamma messenger RNA expression in invasive cervical carcinomas[J]. J Natl Cancer Inst, 1998,90(4):287-294.
  • 5Tovng PL, Chan WY, Lin CT,et al. Decreased expression of human papillomavirus E2 protein and transforming growth factor-betal in human cervical neoplasia as an early marker in carcinogenesis[J]. J Surg Oncol,2003,84(1) :17-23.
  • 6Lu D, Tawfik I, Pantatis C, Hobart W. Chapman J, Ickowski K:Altered expression of ED44and variant isoforms in human adenocarcinoma of the endocervix during progression [J]. Gynecol Onco1,1999,75(1) :84-90.
  • 7Nees M, Geoghegan JM, Munson P, et al. Human papillomavirus type 16 E6 and E7 proteins inhibit differentiation dependent expression of transforming growth factor-beta2 in cervical keratinocytes[J]. Cancer Res ,2000, 60(15) :4289-4298.
  • 8Alfandari J, Shnitman Magal S, Jackman A, et al. HP-V-16 oncoprotein inhibits apoptosis induced during serum calcium differentiation of foreskin human keratinocytes[J]. Virology, 1999,257(2) :383-396.
  • 9Rorke EA,Zhang D,Choock, et al. TGF-beta mediated cell cycle arrest of HPV 16-immortalized ectocervical cells correlates with decreased E6/ETmRNA and increased p53 and p21(WAF-1) expression[J].EXP cell Res, 2000, 259(1):149-157.
  • 10Howard M, Sellors J, Lytwyn A. Cervical intraepithelial neoplasia in women presenting with external genital warts[J]. CMAJ,2002,166(5) z598-599.

共引文献125

同被引文献32

  • 1邢军,刘丽华.阴道镜诊断宫颈人乳头瘤病毒亚临床感染的应用价值[J].中国综合临床,2004,20(7):649-650. 被引量:6
  • 2Jemal A, Bray F, Center MM, et al. Global cancer statistics [ J ]. CA Cancer J Clin,2011,61 (2) :69-90.
  • 3de Bekker-Grob EW, de Kok IM, Bulten J, et al. Liquid-based cervical cytology using ThinPrep technology:weighing the pros and cons in a cost-effectiveness analysis [ J ]. Cancer Causes Control, 2012,23 ( 8 ) : 1323-1331.
  • 4Boonlikit S. Correlation between Reid' s colposcopic index and histo- logic results from colposcopically directed biopsy in differentiating high-grade from low-grade squamous intraepithelial lesion at Rajavithi Hospital [ J ]. J Med Assoc Thai,2011,94 ( Suppl 2 ) : $59 -$65.
  • 5Rogers L, Siu SS, Luesley D,et al. Radiotherapy and chemoradiation after surgery for early cervical cancer [ J ]. Cochrane Database Syst Rev,2012,5 : CD007583.
  • 6Machado FA, Janssens JP, Michelin MA, et al. Immune response and immune- therapy in intraepithelial and invasive lesions of the uterine cervix[ J]. Clin Exp Obstet Gyneeol,2012,39( 1 ) :27-31.
  • 7Saslow D, Solomon D, Lawson HW, et al. American Cancer Society, A- merican Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer[ J]. CA Cancer J Clin,2012,62 (3) :147-172.
  • 8New recommendations from the American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology. Testing for cervical cancer [ J ]. CA Cancer J Clin,2012,62 (3) :211-212.
  • 9Kong CS, Wehon ML, Longacre TA. Role of human papillomavirus in sguamous cell metaplasia dysplasia carcinoma of the rectum. Am J Surg Pathol,2007,31:919- 925.
  • 10Jemal A, Bray F, Center MM, et al. Global cancer statistics [ J ~. CA Cancer J Clin, 2011,61 (2) : 69-90.

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