2型糖尿病并发牙周感染与解偶联蛋白3基因的关系研究

Relationship between type 2 diabetes mellitus complicated by periodontal infection and uncoupling protein 3 gene

目的探讨2型糖尿病并发牙周感染与解偶联蛋白3(UCP3)基因的关系。方法将80例2型糖尿病患者根据是否并发牙周感染分为两组,用聚合酶链反应(PCR)法对两组UCP3基因多态性进行分析并比较。结果并发感染组Ⅲ、D、DD的基因频率分别为39.0%、51.2%、9.8%,与非并发感染组比较,差异无统计学意义;等位基因频率两组间亦差异无统计学意义。结论 2型糖尿病并发牙周感染与解偶联蛋白3基因之间未见明显的关系。

OBJECTIVE To explore the relationship between type 2 diabetes complicated by periodontal infection and uncoupling protein 3（UCP3） gene.METHODS 80 patients with type 2 diabetes were divided into two groups according to whether complicated by periodontal infection.PCR method was used to analyze the polymorphism of UCP3 gene and the results were compared.RESULTS The gene frequencie of II,ID,DD of the infection group was 39.0%,51.2%,9.8%,respectively.There was no significant difference between the two groups（P0.05）.The allele frequency between the two groups had no significant difference（P0.05）.CONCLUSION It shows no significant relationship between type 2 diabetes complicated by periodontal infection and uncoupling protein 3 genes.