多药耐药菌监测与临床分析

Monitoring and clinical analysis of multidrug-resistant bacteria

目的通过对多药耐药菌(MDRO)株的分离和耐药谱检测,为临床有效控制MDRO感染提供依据。方法常规分离培养,鉴定菌种,并进行药敏试验,根据标准筛选MDRO并计算耐药率,同时追踪分析其易感因素。结果 339株多药耐药菌中主要为大肠埃希菌、金黄色葡萄球菌、铜绿假单胞菌、鲍氏不动杆菌、肺炎克雷伯菌等5种病原菌,绝大部分耐>8种常用抗菌药物,其易感因素包括住院时间>2周,使用多种抗菌药物治疗,以及多种有创操作和导管的留置。结论 MDRO对常用抗菌药物几乎全部耐药,应高度重视抗菌药物的合理使用。

OBJECTIVE To provide reference for clinically effective control of multi-drug resistant organism（MDRO） infection trough isolation and detection of drug resistance spectrum of MDRO.METHODS Routine isolation and cultivation,identification of strains,and sensitivity test were performed and calculated according to the standard screening MDRO resistance rates,while tracking to analyze the predisposing factors.RESULTS Of 339 strains of multi-resistant bacteria,the major pathogens were Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Acinetobacter baumannii,and Klebsiella pneumoniae 5 species of bacteria,most of which were resistant to more than 8 commonly used antibiotics,and its predisposing factors included length of stay over 2 weeks,using a variety of antibiotic treatment,and a variety of invasive operations and indwelling catheters.CONCLUSION MDRO are resistant to almost all commonly used antibiotics,it should attach great importance to the rational use of antimicrobial agents.