120例宫颈癌前病变及宫颈癌人乳头瘤病毒(HPV)感染类型分析

Infection Type Analysis about 120 Cases of CIN and Cervical Human Papillomavirus

目的分析宫颈癌前病变及宫颈癌患者人乳头瘤病毒(HPV)感染类型。方法收集清远市妇幼保健院2010年1月至2010年12月确诊为宫颈上皮内瘤变(CIN)及宫颈癌妇女120例,通过PCR和杂交基因芯片技术进行HPV-DNA检测,分析其人乳头瘤病毒(HPV)感染类型。结果 CINⅠ患者46人,CINⅡ患者48人,CINⅢ患者17例,宫颈癌患者9例均为HPV-DNA检测阳性,其中16型46例、52型22例、58型16例、56型11例、33型10例、18型7例,11型、35型、42型、43型、53型、66型、68型和73型各1例。结论宫颈癌前病变及宫颈癌患者人乳头瘤病毒(HPV)感染类型中以高危型为主,尤其是16型,占38.3%;其次为52、58、56和33型,分别占18.3%、13.3%、9.17%和8.3%。

Objective To analyze the cervical intraepithelial neoplasia and the infection type of human papilloma virus（HPV） by carvial cancer patient.Methods To collect 120 patient of Qingyuan MCH who diagnose CIN and carvial cancer,dectection by PCR and hybrid DNA chip technology,and analyze the infection type of HPV.Result There were 46 cases of CIN Ⅰ,48 cases of CIN Ⅱ,17 cases of CIN Ⅲ,and 9 cases of carvical cancer were positive for HPV-DNA,which 46 cases were 16 type,22 cases were 52 type,16 cases were 58 type,11 cases were 56 type,10 cases were 33 type,7 cases were 18 type,1 cases were 11type,1 cases were 35 type,1 cases were 42 type,1 cases were 43 type,1 cases were 53 type,1 cases were 66 type,1 cases were 68 type,1 cases were 68 type,1 cases were 73 type.Conclusion The majority of cervical intraepithelial neoplasia and carvial cancer paitient were high risk type.Especially the 38.3% were the 16 type,and the 18.3% were the 52 type,the 13.3% were the 58 type,the 9.17% were the 56 type,the 8.3% were the 33 type.