期刊文献+

阿尔茨海默病治疗药物研究进展 被引量:2

The research advancement in the therapeutic drugs against Alzheimer's disease
下载PDF
导出
摘要 阿尔茨海默病目前缺乏有效的治疗方法,胆碱酯酶抑制剂和N-甲基-D-门冬氨酸受体拮抗剂可部分改善临床症状,但其它在研药物尚未显示有明显疗效。免疫治疗取得一些研究进展,但仍有待临床验证。本文概要介绍近年来阿尔茨海默病治疗药物的研究进展。 There is still no extremely effective treatment for Alzheimer's disease.Central acetylcholinesterase inhibitors and N-methyl-D-aspartate receptor antagonist can partially improve patient's symptoms.However,the other investigating drugs have not yet been identified to be effective.Some progress has been made in immunotherapy,but further clinical studies are required.This article reviews the progress in medications of Alzheimer's disease.
作者 黄莹 赵重波
出处 《上海医药》 CAS 2011年第6期264-267,共4页 Shanghai Medical & Pharmaceutical Journal
关键词 阿尔茨海默病 治疗药物 胆碱酯酶抑制剂 N-甲基-D-门冬氨酸受体拮抗剂 Alzheimer's disease acetylcholinesterase inhibitor N-methyl-D-aspartate receptor antagonist
  • 相关文献

参考文献15

  • 1Wilkinson D,Schindler R,Schwam E,et al.Effectiveness of donepezil in reducing clinical worsening in patients with mild-to-moderate Alzheimer' s disease[J].Dement Geriatr Cogn Disord,2009,28(3):244-251.
  • 2刘福根,高之旭,陈美娟,马永兴,邵福源,张广歧,瞿正万.加兰他敏片治疗阿尔采末病的多中心、随机双盲评价[J].中国新药与临床杂志,2003,22(1):29-32. 被引量:13
  • 3Erkinjuntti T,Gauthier S,Bullock R,et al.Galantamine treatment in Alzheimer' s disease with cerebrovascular disease:Responder analyses from a randomized,controlled trial (GAL-INT-6)[J].J Psychopharmacol,2008,22(7):761-768.
  • 4Burns A,Bernabei R,Bullock R,et al.Safety and efficacy of galantamine (Reminyl) in severe Alzheimer' s disease (the SERAD study):A randomised,placebo-controlled,double-blind trial[J].Lancet Neurol,2009,8(1):39-47.
  • 5任晓蕾,张海英,李玉珍.石杉碱甲治疗轻、中度阿尔茨海默病有效性和安全性的Meta分析[J].中国药房,2010,21(10):909-913. 被引量:21
  • 6Sano M,Ernesto C,Thomas RG,et al.A controlled trial of selegiline,alpha-tocopherol,or both as treatment for Alzheimer' s disease.The Alzheimer' s Disease Cooperative Study[J].N Engl J Med,1997,336(17):1216-1222.
  • 7Doody RS,Gavrilova SI,Sano M,et al.Effect of dimebon on cognition,activities of daily living,behaviour,and global function in patients with mild-to-moderate Alzheimer's disease:A randomised,double-blind,placebo-controlled study[J].Lancet,2008,372(9634):207-215.
  • 8Yaffe K,Krueger K,Cummings SR,et al.Effect of raloxifene on prevention of dementia and cognitive impairment in older women:The Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial[J].Am J Psychiatry,2005,162(4):683-690.
  • 9Shumaker SA,Legault C,Rapp SR,et al.Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women:The Women' s Health Initiative Memory Study:A randomized controlled trial[J].J Am Med Assoc,2003,289(20):2651-2662.
  • 10DeKosky ST,Williamson JD,Fitzpatrick AL,et al.Ginkgo biloba for prevention of dementia:A randomized controlled trial[J].J Am Med Assoc,2008,300(19):2253-2262.

二级参考文献16

共引文献32

同被引文献62

引证文献2

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部