血清超敏C-反应蛋白在甲型H1N1流感患者中的变化及临床意义

Changes and clinical values of serum high-sensitivity C reaction protein in patients with pandemic influenza A(H1N1)

目的探讨检测血清超敏C反应蛋白(hs-CRP)在甲型H1N1流感患者中的变化及临床意义。方法检测79例(轻症42例、重症37例)甲型H1N1流感患者的血清hs-CRP水平,分析和同期40例普通流感患者的血清hs-CRP水平比较。结果甲型H1N1流感患者血清hs-CRP阳性率明显高于普通流感组,差异具有统计学意义(χ2=40.83,P<0.05);重症甲流组血清hs-CRP水平明显高于轻症甲流组及普通流感组,差异具有统计学意义(F=22.80,P<0.05)。结论血清hs-CRP的检测可作为甲型H1N1流感的早期诊断、病情监测的辅助指标。

Objective To investigate the changes and clinical values of serum high-sensitivity C reaction protein（hsCRP） in patients with pandemic influenza A（H1N1）.Methods Seventy-nine patients（42 mild and 37 severe cases） with pandemic influenza A（H1N1） were enrolled in this study.Meanwhile,40 patients with common influenza at the same stage were served as a control group.The levels of serum hs-CRP in the two groups were detected,analyzed and compared.Results The positive rate of serum hs-CRP in H1N1 group was significantly higher than that of the controls（χ2=40.83,P0.05）.Furthermore,the serum hs-CRP level in the severe H1N1 influenza cases was obviously higher than the mild cases and the controls（F=22.80,P0.05）.Conclusions Detection of serum hs-CRP can help to diagnose early pandemic influenza A（H1N1） and monitor condition changes.