塞利洛尔和阿替洛尔治疗轻中度高血压的随机双盲试验

A randomized double-blind study of atenolol and celiprolol in mild to moderate hypertension

目的:观察塞利洛尔治疗原发性高血压的短期和长期疗效.方法:原发性高血压60例,按4:1的比例随机分为试验组和对照组,分别服用塞利洛尔片和阿替格尔片,疗程6Wk.结果:试验组和对照组降压的总有效率分别为83.0%和86.7%,无显著差异.血压分别下降2.3/1.7 kPa(17.3/12.8mmHg)和2.4/1.7/kPa(18.2/12.8 mmHg),治疗前后差异非常显著.试验组心率下降程度较小,1例感疲乏,1例出现皮疹,无一例因不良反应而停药.结论:塞利洛尔治疗轻、中度原发性高血压安全有效.

AIM : To evaluate the long-term and short term effects of celiprolol in patients with essential hypertension and its side effect. METHODS: Sixty patients with essential hy-pertension were divided into 2 groups and administered celiprolol or atenolol for 6 wk, RE-SULTS: The total efficiency rate were 83.0% for celiprolol group and 83.3% for atenololgroup (P>0.05). The blood pressure decreased from [(21.0 ± 1. 53/13. 77 ± 0. 72)kPa (157. 5 # 11. 5/103. 3 ± 5. 4)mmHg] to [(18. 71 ± 1. 76/12. 07 ± 1. 04)kPa (140. 3 ± 13. 2/ 90. 5 ± 7. 8)mmHg] in celiprolol group and from [(20. 96 ± 1. 83/13. 49 ± 0. 47)kPa (157. 2 ± 13. 7/101. 2 ± 3. 8)mmHg] to [(18. 53 ± 2. 23/11. 79 ± 0. 75)kPa (139. 0 ± 16. 7/88. 4 ± 5. 6) mmHg] in control (P<0. 01). No obvious side effect was found. CONCLUSION: Celiprolol is effective and safe on hypertension.