摘要
目的:比较两种阿昔洛韦片剂的生物利用度.方法:选择10名男性健康志愿者.采用交叉试验设计,给予单剂量口服O.4g阿昔洛韦受试药品和对照药品.采用HPLC法测定血药浓度,比较两种药品的生物利用度和药物动力学参数.结果:受试药品和对照药品的药物动力学参数无显著差异,AUC和C_(max)经三因羹方差分析和双向单侧t检验显示两药的等效性合格.受试药品的相对生物利用度为(97.68±17.84)%.结论:受试药品和对照药品具有生物等效性.
AIM: To compare the bioavailability of 2 preparations of acyclovir. MET-HODS: A single dose of 0. 4 g acyclovir tested tablet and reference tablet were given to 10male subjects with cross-over method. Plasma concentration of acyclovir was determined by high performance liquid chromatography. Pharmacokinetic parameters and bioavailability of 2 preparations were compared. RESULTS: No significant differences had been observed in pharmacokinetic parameters between tested and reference preparations. The relative bioavailability of tested tablet was (97. 68 ± 17. 84)% when compared with reference tablet. CONCLUSION: The 2 preparations of acyclovir are bioequivalent.
出处
《中国临床药学杂志》
CAS
1999年第5期287-290,共4页
Chinese Journal of Clinical Pharmacy
关键词
阿昔洛韦
生物利用度
高效液相色谱法
acyclovir
bioavailability
high performance liquid chromatography
