慢性肝病患者血清可溶性细胞间粘附分子-1和透明质酸水平的变化及意义

Serum Concentration of Soluble Intercellular Adhesion Molecule-1 Hyaluronic Acid and Their Clinical Significance in Chronic Liver Diseases

目的:探讨血清可溶性细胞间粘附分子-1(sICAM-1)和透明质酸(HA)与肝纤维化及肝损害的关系。方法:用ELISA法检测正常人、慢性肝炎肝硬变患者血清sICAM-1;用RIA法测定正常人、慢性肝炎及肝硬变患者血清HA。结果:慢性肝病患者各组血清sICAM-1均显著高于正常人,各组间存在显著的差异。血清HA水平在慢性肝炎中度组、重度组、肝硬变组明显高于正常人。在不同临床类型的慢性肝病患者中HA血清水平也存在显著的差异。病情越重,血清sICAM-1和HA水平越高。两者与血清草酰乙酸转氨酶(AST)、总胆红素、球蛋白呈显著正相关,与血清白蛋白呈显著负相关。结论:慢性肝病患者血清sICAM-1和血清HA可作为判断肝纤维化及肝损伤程度的指标。

Aim: To study the relation between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1 ). hyaluronic acid (HA) and hepatic fibrosis, liver damage in patients with chronic liver diseases. Methods: Serum levels of sICAM-1 and HA were measured by ELISA or RIA in 106 patients with chronic liver diseases and 30 healthy persons. respectively. Results: Serum levels of sICAM-1 in patients with chronic liver diseases were significantly increased, compared with healthy persons. While serum levels of HA in patients with chronic moderate hepatitis. chronic severe hepatitis and liver cirrhosis were also higher than those in patients with chronic mild hepatitis and healthy persons. The serum levels of sICAM-1. HA in differnt stages gradually increase with the progression of liver damage A significantly positive correlation among serum levels of sICAM-1 and AST. total bilirubin, globulin and also serum levels of HA and serum AST, total bilirubin,globulin could be observed. A markedly negative correlation between sICAM-1 and serum albumin. HA and serum albumin were found. Conclusion:①Serum levels of sICAM-1 and HA are two clinical markers for determining hepoatic fibrosis. ②Serum levels sICAM-1 and HA may reflect the damage of liver.