儿童髓母细胞瘤术后放疗、化疗的治疗进展

Advances in Treatment of Medulloblastomas in Children

髓母细胞瘤（MB）好发生于儿童,约占儿童脑肿瘤的17.7%,3岁以下者占儿童MB的25%-30%。MB的恶性程度较高,单纯手术不易完全切除,但MB对放疗、化疗多较敏感。目前标准治疗方案是进行手术,然后接受放疗和化疗。近年来,许多研究者对术后放疗、化疗的方案进行了大量研究,希望能够在保证较好疗效的前提下,减少患者不良反应。现就近年来术后放疗、化疗方案的研究进展进行综述。

Medulloblastoma（MB） occurs mostly in children.This accounts for 17.7% of primary central nervous system tumors in children.These children less than 3 years old accounts for 25%-30% of children with MB.MB has higher malignant degree,not completely removed with surgery done easily,and it is more sensitive to radiotherapy and chemotherapy.Current treatment strategy for MB patients is surgery followed by radiation and chemotherapy.Various regimens of postoperative radiotherapy and chemotherapy have been investigated recently in order to improve the outcomes and avoidits side effect.In this article,the recent advances in the treatment of MB were reviewed.