摘要
目的 探讨2型糖尿病对骨代谢紊乱及相关激素的影响。方法 测定20例健康对照者和60例2型糖尿病患者血甲状旁腺激素(PTH)、降钙素(CT)、25羟维生素D3 〔25(OH)D3〕、环磷酸腺苷(cAMP)和血、尿钙(Ca)、磷(P)、镁(Mg)、糖基化血红蛋白(HbA1c)、24小时尿糖、C肽曲线下面积等指标。结果 ①2型糖尿病患者血PTH 水平显著高于对照组(P< 0.001和P< 0.01),CT水平显著低于对照组(P< 0.01),尿Ca、尿Mg 排泄量显著高于对照组(P< 0.01和P< 0.05);②PTH水平与HbA1c和尿Ca 呈显著正相关(r= 0.40,P< 0.05和r= 0.83,P< 0.001),与CT呈显著负相关(r= - 0.74, P< 0.01);③PTH水平与C肽曲线下面积呈负相关(r= - 0.31, P< 0.2)。结论 2型糖尿病患者存在明显Ca、Mg 代谢异常和继发性PTH、CT改变是造成骨质疏松的主要原因,这种变化在糖尿病早期更明显。
Objective To explore the effect of type 2 diabetes mellitus on bone metabolism disorder and the related hormones. Methods Serum parathyroid hormone(PTH)、 calcitonin (CT)、25 hydroxycholecalciferol〔25(OH)D 3〕、cyclic adenosine monophosphate(cAMP) and serum calcium (Ca)、phosphorus(P)、magnesium (Mg) and urinary Ca、P、Mg and glycosylated hemoglobin (HbA1c), and 24 hour urinary glucose excretion were mearsured in 20 healthy subjects and 60 type 2 diabetic patients.Results ①PTH level was obviously increased (P<0 001)and CT level was markedly decreased in diabetic groups (P<0 01), and urinary Ca、Mg excretion was apparently increased (P<0 01 and P<0 05);②The level of PTH was remarkably positively correlated with the HbA1c and urinary Ca(r=0 40,P<0 05 and r=0 83,P<0 001),and was remarkably negatively correlated with CT(r=-0 74,P<0 01);③The area under the C peptide curved line was negatively correlated with PTH (r=-0 31,P<0 2).Conclusion These results suggested that type 2 diabetic patients had Ca、Mg metabolism disorder and secondary PTH、CT changes, which were the main cause of the osteoporosis and more remarkable in early duration. Poor glucose control accelerated the development and progression of bone metablism disorder.
出处
《中国糖尿病杂志》
CAS
CSCD
1999年第5期273-276,共4页
Chinese Journal of Diabetes
关键词
2型
糖尿病
骨代谢
钙
激素
骨质疏松
Type 2 diabetes mellitus Bone metabolism Calcium regulating hormones