摘要
目的研究ＣＤ(１５)和抑癌基因蛋白产物在膀胱癌组织中的表达及与病理分级、临床分期、复发和转移的关系，并探讨ＣＤ(１５)与抑癌基因蛋白表达的相关性。方法应用微波－ＬＳＡＢ免疫组织化学法，检测５２例膀胱癌组织中ＣＤ(１５)和ｐ５３的表达水平。结果在膀胱癌中ＣＤ(１５)和ｐ５３阳性表达率分别为６９．２％和４８．１％。其表达均与肿瘤分级、分期、复发和转移相关（Ｐ＜０．０５）。ＣＤ(１５)和Ｐ５３表达里正相关。结论ＣＤ(１５)和Ｐ５３均是膀胱癌高度恶性和预后不良的重要生物学指标。膀胱癌ＣＤ(１５)表达与Ｐ５３蛋白表达可能具有相互协同作用。
Objective To study the relationship between expression of CD15 and antioncogene and tumorgrade, clinical staging, recurrence and metastasis. Methods Microwave-LSAB immunohistochemicaltechnique was used to investigate the expression of CD15, and p53 in 52 bladder carcinoma. Results Thepositive rate of CD,, and p53 was 69. 2% and 48. 1 %. It was positively correlated with tumor grade,clinical staging,recurrence and metastasis (P<0.05 ). Expression of CD15 was significantly correlated withthe expression of p53. Conclusion CD15 and p53 might be important biologic marker for evaluating themalignancy and prognosis of bladder carcinoma. There might be some coordinated regulation among them.
出处
《肿瘤研究与临床》
CAS
1999年第5期312-313,共2页
Cancer Research and Clinic
