血清CA72-4、补体C3a和恶性肿瘤特异性生长因子联合检测在贲门癌诊断中的应用

Clinical value of combined detection of CA72 -4, complement C3a and TSGF levels in diagnosis of gastric cancer

目的探讨CA72—4、补体C3a和恶性肿瘤特异性生长因子（TSGF）在贵门癌患者血清中的水平，以及三者联合检测在贲门癌临床诊断中的价值。方法采用电化学发光免疫分析法检测80例贲门癌患者（贲门癌组）、60例贲门良性疾病患者（良性疾病组）、50例健康体检者（对照组）血清中CA72—4、补体C3a、TSGF的浓度，并对单项及联合检测诊断贲门癌的敏感性、特异性、阳性预测值、阴性预测值进行比较，探讨其联合诊断的效能。结果贲门癌患者血清中CA72—4、补体C3a、TSGF的含量明显高于贲门良性疾病组及健康对照组，差异有统计学意义（P〈0．01）。联合检测血清CA72—4、C3a和TSGF对贲门癌诊断敏感性为84．6％，特异性为93．8％，阴性预测值91．3％，与单项检测贲门癌敏感性、特异性和阴性预测值相比较，差异有统计学意义（P〈0．05）。结论CA72—4、补体C3a、TSGF可作为临床诊断贲门癌的肿瘤标志物，3项联合检测可明显提高贲门癌的诊断敏感性。

Objective To investigate the clinical value of CA72 -4, complement C3a and tumor specific growth factor （TSGF） in serum of gastric cancer patients and the significance of their combined detection in diagnosis of cardiac cancer. Methods Serum levels of CA72 -4, comple- ment C3a and TSGF were detected using electrochemiluminescence immunoassay （ECL） in 80 patients with cardiac cancer （ cardiac group） , 60 patients with benign cardiac disease （ benign disease） , 50 healthy subjects （control group）. The diagnostic value of these tumor markers were analyzed by sensitivities, specificities, positive predictive value and negative predictive value with single and joint detection. Results The levels of CA72 -4, complement C3a and TSGF in the cardiac cancer group were higher than those in gastric benign disease and normal healthy groups, and the difference was statistically significant （ P 〈 0.01 ）. The diagnostic sensitivity of combined detection of serum CA72 - 4, com- plement C3a and TSGF for cardiac cancer was 84.6% , specificity was 93. 8% , and the negative predictive value was 91.3 % , and they were higher than those of the single detection cardiac sensitiv- ity, specificity and negative predictive value, the difference was statistically significant （ P 〈 0.05 ）. Conclusions CA72 -4, complement C3a and TSGF may be used as the serum tumor markers in the clinical diagnosis of cardiac cancer. The combined detection of three kinds of serum tumor makers can significantly improve the diagnostic sensitivity of cardiac cancer. significant （ P 〈 0.01 ）. The diagnostic sensitivity of combined detection of serum CA72 - 4, complement C3a and TSGF for cardiac cancer was 84.6% , specificity was 93. 8% , and the negative predictive value was 91.3 % , and they were higher than those of the single detection cardiac sensitiv- ity, specificity and negative predictive value, the difference was statistically significant （ P 〈 0.05 ）. Conclusions CA72 -4, complement C3a and TSGF may be used as the serum tumor markers in the clinical diagnosis of cardiac cancer. The combined detection of three kinds of serum tumor makers can significantly improve the diagnostic sensitivity of cardiac cancer.