纳络酮联合甲氯芬酯治疗重度颅脑外伤的临床效果观察

Clinical Efficacy of Severe Traumatic Brain Injury Treated by Naloxone and Meclofenoxate

目的探讨纳络酮联合甲氯芬酯治疗重度颅脑外伤的临床效果。方法将200例重度颅脑外伤的患者随机分为4组,Ⅰ组患者采用常规治疗,Ⅱ组患者在Ⅰ组的基础上加用纳洛酮治疗,Ⅲ组患者在Ⅰ组患者的基础上加用甲氯芬酯治疗,Ⅳ组患者在Ⅰ组患者的基础上,联合使用纳络酮和甲氯芬酯治疗。观察4组患者疗效和预后情况。结果Ⅳ组患者与Ⅰ组、Ⅱ组、Ⅲ组患者相比,患者疗效和预后更好,经统计学分析,P<0.05,差异有统计学意义。Ⅱ组与Ⅲ组患者相比,差异不明显,P>0.05,差异无统计学意义。结论纳络酮联合甲氯芬酯治疗重度颅脑外伤疗效较好,值得在临床中推广使用。

Objective Of naloxone Meclofenoxate joint treatment of severe traumatic brain injury clinical effects.Methods 200 patients with severe head injury were randomly divided into 4 groups,Ⅰ group were treated with conventional therapy,Ⅱ in the Ⅰ group of patients based on the use of naloxone treatment,Ⅲ patients in the Ⅰ group of patients based on the use meclofenoxate treatment,Ⅳ patients in the I group of patients,based on the joint use of naloxone and meclofenoxate treatment.4 groups were observed effect and prognosis.Result Group Ⅳ patients with Ⅰ,Ⅱ group,Ⅲ group compared with patients,better patient outcomes and prognosis,the statistical analysis,P〈0.05,the difference was statistically significant.Ⅱ group and Ⅲ group compared with patients not significantly different,P〉0.05,the difference was not statistically significant.Conclusion Naloxone treatment of joint meclofenoxate good effect in severe brain injury,it is worth promoting in clinical use.