肝硬化患者血IL-1β、TNF-α及尿crosslaps水平与骨密度关系

The Relationship Between Serums Levels of IL-1β,TNF-α,Urine Crosslaps and Bone Mineral Density of Liver Cirrhosis Patients

目的探讨血清IL-1β、TNF-α及尿Crosslaps变化对肝硬化患者骨密度变化的影响。方法测定46例肝硬化患者血清IL-1β、TNF-α及尿Crosslaps水平及骨密度,并与25例健康者对照。结果 :肝硬化组血清IL-1β、TNF-α及尿Crosslaps水平显著升高(P<0.05),骨质疏松组(OP)较非骨质疏松(NOP)升高更显著(P<0.05),OP组IL-1β、TNF-α及尿Crosslaps水平与骨密度呈负相关。结论 IL-1β、TNF-α及尿Crosslaps水平升高导致骨吸收增强,参与了肝性骨病的发生,降低体内IL-1β、TNF-α及尿Crosslaps水平对HBD防治有一定作用。

Objective To investigate the relationship between serums levels of IL-1β,TNF-α,urine crosslaps and bone mineral density of liver cirrhosis patients.Methods Levels of IL-1β,TNF-α,urine crosslaps were detected in 46 liver cirrhosis patients and 25 age-matched healthy controls.Results The levels of IL-1β,TNF-α,urine crosslaps in liver cirrhosis patients increased more than that of controls（P〈0.05）,osteoporosis（OP） group＇s much higher than non-osteoporosis（NOP） group＇s.we also found the levels of IL-1β,TNF-α,urine crosslaps in OP group＇s had negative correlation with mean bone density.Conclusion The elevation of serum IL-1β、TNF-α and urine crosslaps can accelerate bone resorption and lead to hepatic bone disease（HBD）.Reducing the concentration and blocking the effect of serum IL-1β,TNF-α and urine crosslaps may be very important for prevention and treatment of HBD.