生长抑素治疗急性胰腺炎的临床研究

EVALUATION OF SOMATOSTATIN IN THE TREATMENT OF ACUTE PANCREATITIS

目的 探讨生长抑素治疗急性胰腺炎的临床效果。方法 应用人工合成的生长抑素类似物——奥曲肽治疗３８例和非奥曲肽治疗５９ 例急性胰腺炎。观察了两组以及奥曲肽治疗用药前后血清淀粉酶及胰液淀粉酶的含量，比较了两组并发症的发生率。结果 奥曲肽能有效降低血清淀粉酶和胰液淀粉酶的活性，改善临床症状和体征，降低并发症的发生。结论 奥曲肽有助于急性胰腺炎的治疗。

ObjectiveTo evaltuate the curative effects of somatostatin on the acute pancreatitis.Methods We used octreotide-an analogue of Somatostatin to treat 38 cases of acute pancreatitis.59 patients were treated by non-octreotide as the control group.Before and after the drug of hypodermic injection ,the serum amylase and pancreatic fluid amylase were simultancously quantitative analyzed for both groups.And the incidence of complications in these patients were compared also.By contrast,we observed that octreotide could significantly decrease the levels of serum and pancreatic fluid amylase.Results Octreotide could ameliorate the clinical symptoms and signs,decrease the occurances of complication.Conclusion Octreotide may be contributed to the treatment of the acute pancreatitis.