选择性动脉插管化疗联合放疗对晚期鼻咽癌的近期疗效观察

The Preliminary Results of Combination of Selective Arterial Chemotherapy With Radiotherapy in The Treatment of Advanced Nasopharyngeal Carcinoma

目的 观察选择性动脉插管化疗在晚期鼻咽癌综合治疗中的应用价值。方法 选择 70例局部晚期鼻咽癌初治患者 ,随机分成 2组各 3 5例 ,分别进行选择性动脉插管化疗 ( IACT)加放疗和全身化疗 ( SCT)加放疗 ,并采用配对的方法选择同期单纯放疗 ( RT)的鼻咽癌患者作为对照组 ,于放疗后对 3组的疗效进行比较。结果 IACT组完全缓解率及 2年局控率为65 .7%及 82 .9% ,SCT组为 5 4 .3 %和 77.1% ,RT组为 4 2 .9%及 5 1.4 %。结论 选择性动脉插管化疗加放疗治疗晚期鼻咽癌 ,短期疗效显著 ,副作用轻。

Purpose\ To evaluate the clinical value of selective arterial chemotherapy and radiotherapy in treating the advanced nasopharyngeal carcinoma Methods\ Seventy patients with advanced nasopharyngeal carcinoma(stage Ⅲ or Ⅳ)were randomized to receive either combined elective arterial chemotherapy and radiotherapy (IACT group, 35 patients) or combined general intravenous chemotherapy and radiotherapy (SCT group, 35 patients) The patients in another control group were treated with conventional radiotherapy (RT group, 35 patients) After radiotherapy, the effect of three methods was compared Results\ The total improved rate and the 2-year local disease control rate were 65 7% and 82 9% in IACT, 54 3% and 77 1% in SCT,42 9% and 51 4% in RT Conclusion\ The short-term therapeutic results of selective arterial chemotherapy combined with radiotherapy in advanced nasopharyngeal carcinoma was effective obviously