安宫牛黄丸治疗蛛网膜下腔出血后脑血管痉挛疗效观察

Clinical observations on treatment with Angong Niuhuang Pill(安宫牛黄丸 ) for cerebral vasospasm following subarachnoid hemorrhage

目的 :观察安宫牛黄丸治疗蛛网膜下腔出血后脑血管痉挛的疗效。方法 :4 8例患者随机分为治疗组和对照组 ,各 2 4例 ,治疗组给安宫牛黄丸 ,每次 3 g,2次 /日 ,对照组给尼莫地平 ,每次 60 mg,4次 /日。分别测 2组用药前 3 0分钟 ,用药后 3日及 12日脑血流速度并评定疗效。结果 :治疗组大脑中动脉平均血流速度由 ( 168± 4 9) cm/s降至 ( 96± 2 5 ) cm/s;对照组由 ( 171± 3 8) cm/s降至 ( 117± 3 4) cm/s,2组比较有显著性差异 ( P<0 .0 1)。同时治疗组疗效优于对照组。结论

Objective:To observe the curative effects of Angong Niuhuang Pill ( AGNHP,安宫牛黄丸 ) on cerebral vasospasm following subarachnoid hemorrhage ( SAH ) .Methods:4 8patients were randomly divided into treatment and control group.The treatment group was treated with AGNHP 3 g two times a day while control group treated with nimodipine 60 m g four tim es a day.3 0 minutes before using drug and the third day as well as twelfth day after using drug the speed of cerebral blood flow was detected and the curative effects were evaluated respectively in two groups.Results:In treatm ent group the mean speed of blood flow in cerebral middle artery was declined from ( 168± 4 9) cm / s to ( 96± 2 5 ) cm / s but in control group it was declined from ( 171± 78) cm/ s to ( 117± 3 4) cm / s.The difference was significant ( P<0 .0 1) .Simultaneously the curativs ef- fects in treatmentgroup were superior to that in control group.Conclusions:AGNHP possesses better curative effects in treating cerebral vasospasm following SAH.