妊娠期高血压疾病患者血清抵抗素水平的变化及其临床意义

Changes and clinical value of serum resistin level in patients with hypertensive disorders in pregnancy

目的探讨妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)患者血清抵抗素(Resistin)水平的变化及其临床意义。方法以100例妊娠期高血压疾病患者为研究对象,其中轻度子痫前期69例,重度子痫前期31例;选取同期100例正常孕晚期孕妇为对照组。采用酶联免疫分析法(enzyme-linked immunosorbent assay,ELISA)检测孕妇血清抵抗素水平,同时检测空腹血糖(fasting blood glucose,FBG)水平、空腹胰岛素(fasting insulin,FINS)水平,计算胰岛素抵抗指数(insulin resistance index,IRI)。结果轻度、重度子痫前期患者血清抵抗素水平分别为(0.72±0.66)μg/ml和(0.84±0.45)μg/ml,明显高于对照组(0.41±0.33)μg/ml,差异有统计学意义(P<0.05)。轻度、重度子痫前期患者胰岛素抵抗指数明显高于对照组(P<0.05),抵抗素水平与胰岛素抵抗指数呈显著正相关(r=0.419,P<0.05)。结论抵抗素水平在妊娠期高血压疾病患者中明显升高,抵抗素水平与胰岛素抵抗指数呈显著相关性,提示抵抗素在妊娠期高血压发病中可能起着一定的作用,其作用机制与增加胰岛素抵抗有关,可能成为HDP发病及严重程度的预测指标之一。

Objective To investigate the changes and clinical purpose of serum resistin level in patients with hypertensive disorders in pregnancy（HDP）.Methods The serum resistin and fasting blood glucose（FBG）,fasting insulin（FINS） were measured by enzyme-linked immunosorbent assay（ELISA） and insulin resistance index（IRI） were calculated through the value of FBG and FINS in 100 HDP patients and 100 normotensive pregnant women.All of 200 women were divided into three groups as mild pre-eclampsia group with 69 cases,severe pre-eclampsia group with 31 cases and control group with 100 normotensive pregnant women.Results The serum resistin level of mild pre-eclampsia group and severe pre-eclampsia group as（0.72±0.66） μg/ml and（0.84±0.45）μg/ml respectively was higher than that as（0.41±0.33） μg/ml of control group that the difference was significance（P0.05）.The insulin resistance index（IRI） of mild pre-eclampsia group and severe pre-eclampsia group was higher than that of control group respectively that the difference was significance（P0.05）.There was the positive correlation between the serum resistin level and IRI（r=0.419,P0.05）.Conclusion The serum resistin level is higher significantly in HDP patients than that of normotensive pregnant women and positive correlation does exist between the serum resistin level and IRI.The research suggests that the serum resistin play a role in the pathogenesis of HDP which has relationships with increasing insulin resistance.The serum resistin level may be the predictor of the incidence and the severity of HDP.