O-糖苷键连接的N-乙酰葡萄糖胺修饰及其心血管保护作用的研究进展

Advance in O-GIcNAc modification and its cardiovascular protective effects

背景 蛋白0精苷键连接的N-乙酰葡萄糖胺（O-GlcNAc）修饰是一种广泛存在的、动态的转录后修饰方式，通过N-乙酰氨基葡萄糖转移酶（β-N-acetylglucosaminyltransferase，OGT）及N-乙酰氨基葡萄糖苷酶（O-GlcNAcase，OGA）将N一乙酰葡萄糖胺单糖添加或移除到蛋白质的丝／苏氨酸残基上，在许多生化过程中起到重要作用。目的 在短时间内提高0-GlcNAc修饰水平能够产生显著的心血管保护作用。探讨其作用的具体机制及靶点蛋白。内容 其主要可能机制包括：①抗炎症反应；②促热休克蛋白生成；③抑制细胞凋亡等。趋向 O-GlcNAc修饰改善心血管机能的机制探讨已成为研究热点，对其涉及信号通路的深人了解可能为心血管功能障碍的临床治疗提供一个良好的前景。

Background O-linked attachment of the monosaceharide-N -acetylglucosamine（O-GlcNAc） is a highly dynamic and ubiquitous posttranslational protein modification, plays a critical role in regulating numerous biological processes. O-GlcNAc transferase and O-GleNAcase are responsible for the addition and removal of O-GIcNAc from serine/threonine residues, respectively. Objective To review the potential mechanisms of o-GlcNAc modification and the target protein. Content Main potential mechanisms of O-GIcNAc modification include antagonizing inflammatory, increasing synthesis of HSPs, inhibiting apoptosis, etc. Trend Further insights into the signal pathway of o-GleNAc modification may provide a nice prospect for the therapy of eardiovascular dysfunction.