金礞石人工胃液和水溶性浸出物及其主要元素分析

Analysis of Major Leaching Elements of Lapis Micae Aureum in Simulated Gastric Juice and Water Extract

目的:分析金礞石人工胃液和水溶性浸出物及其主要元素,为金礞石药用有效成分的研究提供参考资料。方法:对金礞石药材进行人工胃液浸出和水煎煮浸出,测定浸出率,并采用ICP-AES测定浸出液中主要元素含量。结果:样品的人工胃液浸出率在5%以上,浸出液中主要元素为Ca,Mg,其次为Fe,Al;样品水煎煮的浸出率及各元素的浸出量均较低。结论:金礞石在临床上多用于丸散少见于汤剂是有科学依据的,其药用物质基础可能与Ca,Mg等人工胃液浸出元素有关。

Objective：To study the active component of Chinese traditional medicine Lapis Micae Aureum in simulated gastric juice and water extract.Method：Simulated gastric juice and boiled water were used for leaching,and then both of the leaching rates were measured.The major elements of the extracts were determined with ICP-AES.Result：The leaching rate of simulated gastric juice was above 5%,that＇s much higher than water leaching rate,which was less than 0.4%.The major leaching elements in extract of simulated gastric juice were Ca and Mg,and also there were some Fe and Al.Conclusion：It is reasonable that Lapis Micae Aureum usually used as pills and powder rather than decoction in clinical.Ca and Mg may relate to its therapeutical effect.