经皮穴位电刺激对酒精依赖患者戒断期的治疗作用

THERAPEUTIC EFFECTS OF TRANSCUTANEOUS ELECTRIC ACUPOINT STIMULATION ON ABSTINENT ALCOHOL-DEPENDENT PATIENTS

目的:评价2/100 Hz经皮穴位电刺激对酒精依赖患者戒断期的作用。方法:将92例符合ICD-10中酒依赖诊断标准的戒断期患者随机分成两组:HANS组(治疗组)45例,给予2/100 Hz经皮穴位电刺激(HANS);Mock-HANS组(对照组)47例,给予模拟经皮穴位电刺激(Mock-HANS),为期15 d。比较两组治疗保持率、平均红细胞体积(MCV)、焦虑症状评分。结果:(1)在治疗15 d时,Mock-HANS组和HANS组的治疗保持率分别为50.0%和87.5%,二者比较差异有显著性(P<0.05);(2)Mock-HANS组的MCV在治疗前、后分别为107.9±s18.7(fL)和100.5±s11.5(fL);HANS组的MCV在治疗前、后分别为108.8±s14.9(fL)和87.8±s9.0(fL),HANS组的MCV平均值在治疗后明显降低(P<0.05),同时也低于Mock-HANS组治疗后(P<0.05);(3)Mock-HANS组焦虑症状评分在治疗前、后分别为26.1±s11.4和18.8±s7.9;HANS组的焦虑症状评分在治疗前、后分别为27.4±s9.4和8.4±s4.6,差异有显著性(P<0.001),其治疗后评分也低于Mock-HANS组治疗后(P<0.001)。结论:2/100Hz经皮穴位电刺激能够提高患者的治疗保持率,恢复血MCV,缓解焦虑症状。

Objective：To evaluate the therapeutic effects of 2/100 Hz transcutaneous electric acupoint stimulation（TEAS）on abstinent alcohol-dependent patients.Methods：Ninety two eligible alcohol-dependent patients in abstinent stage who measured up the criteria of ICD-10 were randomly divided into two groups,HANS（n=45）and Mock-HANS（n=47）.The HANS group and Mock-HANS group received 2/100 Hz TEAS treatment and simulated TEAS treatment,respectively for 15 days.Data were collected at the beginning and the end of the 15-day therapy.The comparisons focused on therapy retention rate,blood mean corpuscular volume（MCV）and anxiety symptom scores before and after treatment.Results：（1）87.5% patients in HANS group still received treatment on day 15,while 50.0% patients in Mock-HANS group did with the HANS group having higher therapy retention rate（P0.05）.（2）The MCV before and after treatment in Mock-HANS group were 107.9±s 18.7（fL）and 100.5±s 11.5（fL）,respectively,while MCV in HANS group decreased from 108.8±s 14.9（fL）to 87.8±s 9.0（fL）,showing statistically significant difference between the two groups（P0.05）.（3）The anxiety symptom scores before and after treatment in Mock-HANS group were 26.1±s 11.4 and 18.8±s 7.9,respectively,while anxiety symptom scores in HANS group decreased from 27.4±s 9.4 to 8.4±s 4.6（P0.001）;the anxiety symptom score in HANS group decreased significantly faster than that in Mock-HANS group.Conclusion：Patients who received 2/100 Hz TEAS treatment have higher therapy retention rate than Mock-HANS group;the TEAS treatment can recover patient＇s blood MCV,and relieve their anxiety symptoms.