不伴精神症状的苯丙胺类兴奋剂依赖者脑干听觉诱发电位的研究

STUDY OF BRAINSTEM AUDITORY EVOKED POTENTIALS IN AMPHETAMINE-TYPE STIMULANTS ADDICTS WITHOUT MENTAL SYMPTOMS

目的:探讨不伴精神症状的苯丙胺类兴奋剂依赖者脑干听觉诱发电位(BAEP)的特点。方法:使用意大利百胜有限公司Galileo S irius全数字化32导脑诱发电位仪对35例此类苯丙胺类兴奋剂依赖者和34例正常人脑干听觉诱发电位的变化进行对照分析。结果:该类苯丙胺类兴奋剂依赖者的BAEP特点为波形稳定性较差,基线易漂移,其波Ⅰ、Ⅲ、Ⅴ出现率100%,波Ⅱ91.4%,波Ⅳ85.7%,波Ⅵ60.0%,波Ⅶ62.9%;波Ⅴ和波Ⅶ的绝对潜伏期均较正常对照组延长,其中波Ⅴ差异有显著性(t=-2.005,P=0.049);波Ⅶ差异有高度显著性(t=-2.966,P=0.004);绝对波幅波Ⅲ和波Ⅴ均较正常对照组降低,其中波Ⅲ差异有显著性(t=2.327,P=0.023),波Ⅴ差异有高度显著性(t=3.259,P=0.002)。结论:不伴精神症状的苯丙胺类兴奋剂依赖者脑干听觉诱发电位具有波Ⅴ潜伏期延长和波幅降低、波Ⅲ波幅降低、波Ⅶ潜伏期延长的特点,可作为其电生理的辅助性诊断。

Objective：To discuss the change of brainstem auditory evoked potentials（BAEP） in amphetamine-type stimulants（ATS） addicts without mental symptoms.Methods：The BAEP of 35 cases of ATS addicts and 34 cases of normal control were comparably analyzed in Galileo Sirius 32 channels digitalevoked potential system.Results：The wave forms were unstable in ATS addicts with waves Ⅰ,Ⅲ,Ⅴ occurred 100%,wave Ⅱ 91.4%,Ⅳ 85.7%,Ⅵ 60.0% and Ⅶ 62.9%.Compared with the normal,the ATS addicts＇ BAEP delayed absolute latencies in waveⅤ,Ⅶ（t=-2.005,P=0.049;t=-2.966,P=0.004）,and decreased absolute amplitudes in waveⅢ,Ⅴ（t=2.327,P=0.023;t=3.259,P=0.002）.Conclusion：The characters of BAEP may be used as auxiliary diagnostic criteria for ATS addicts.