超敏C-反应蛋白检测在新生儿感染性疾病中的意义

Significance of detection of high sensitivity C-reactive protein in neonatal infectious disease

目的:探讨超敏C-反应蛋白(hsCRP)在新生儿细菌感染性疾病诊断中的临床意义。方法:采用荧光免疫法对64例疑似细菌感染性疾病的新生儿静脉血进行hsCRP测定,作为观察组;同时测定50例正常新生儿作为对照组。结果:治疗前观察组的新生儿血清hsCRP为(46.8±16.5)mg/L;对照组为(1.39±0.59)mg/L;观察组的新生儿血清hsCRP明显高于对照组,两者比较差异有统计学意义(P<0.05)。结论:hsCRP检测操作简单,标本用量小,结果准确可靠,是新生儿感染性疾病早期诊断的指标之一,可用于新生儿细菌感染性疾病治疗效果的检测。

Objective To explore the clinical significance of high sensitivity C-reactive protein（hsCRP） in the diagnosis of neonatal bacterial infections.Method The venous blood hsCRP levels of 64 neonates of suspected bacterial infections in our hospital were detected with fluorescence immunoassay,and 50 normal newborns were simultaneous detected as the control group.Results Before treatment,the serum hsCRP level of the bacterial infection group was（46.8 ± 16.5） mg/L,the control group was（1.39 ± 0.59） mg/L;the bacterial infection group was significantly higher than the control group,and the difference was significant（P0.05）.Conclusion hsCRP test has the advantages of simple,small expenses of sample,accurate and reliable,is one of the early diagnosis indicator of neonatal infectious disease,can be used in treatment efficacy test of neonatal bacterial infections.