大戟二萜结构及其生理活性研究进展(Ⅰ)——曼西醇及其相关碳骨架二萜醇类

PROGRESS IN THE STRUCTURES OF DITERPENOIDS AND THEIR BIOACTIVITIES FROM EUPHORBIA GENUS(Ⅰ)——Diterpenoids of relative Myrisinol types

从大戟属植物中已发现 15种碳骨架类型的二萜化合物。本文综述了其中曼西醇二萜类及其相关碳骨架二萜醇类 ( 14β-羟基曼西醇 ,阿勒颇测大戟醇和鸡肠狼毒大戟醇型 )的结构及它们的刺激性、抗癌性和杀菌作用等生理活性和生物合成关系的研究。其中包括 4种新碳骨架醇的 33个高氧化型二萜多酯类。

A great number of diterpenoids owning fifteen carbon skeleton types have been obtained from the genus Euphorbia still now.In this paper,the structures of myrisinol and its relative diterpenoids(14β myrisinol,euporeppinol and sprol esters),and their irritating,anticancer and bactericide activities as well as the possible biosynthetic pathway,were reviewed,including 33 polyfunctional diterpene ester with four novel carbon skeleton types(myrisinol,14β myrisinol,euporeppinol and sprol).