艾司西酞普兰联合喹硫平治疗难治性抑郁症疗效观察

Observation of Escitalopram Combined with Risperidone in the Treatment of Treatment Resistant Depression

目的了解艾司西酞普兰联合喹硫平治疗难治性抑郁症的疗效和不良反应。方法将患者分为研究组和对照组,研究组服用艾司西酞普兰和喹硫平,对照组服用艾司西酞普兰,疗程为8周。治疗前、治疗后第2、4、6、8周末分别采用汉密尔顿抑郁量表（HAMD）和临床总体印象量表（CGI）评定,依据HAMD总分减分率判定临床疗效。不良反应采用副反应量表（TESS）评定。结果研究组有效率70.59%,对照组有效率45.16%,两组相比差异有统计学意义（χ2=4.32,P〈0.05）。在第4周时HAMD评分研究组与对照组相比有统计学差异（t=2.61,P〈0.05）,第6周时CGI评分研究组与对照组相比有统计学差异（t=2.24,P〈0.05）,不良反应两组无统计学意义。结论艾司西酞普兰联合喹硫平能提高治疗难治性抑郁症的疗效。

Objective To explore clinical efficacy and adverse effect of Escitalopram combined with quetiapine in the treatment of treatment resistant depression.Methods The patients were randomly assigned to two groups： research and control group.The patients were administered with Escitalopram and Quetiapine in research group,the patients were administered with Escitalopram alone,and evalulated with Hamilton Depressive Scale（HAMD）,Clinical Global Impression Scale（CGI）,and Treatment Emergent Symptom Scale（TESS） before treatment and 2,4,6,8 weeks after treatment.The effects was assessed by the reducing score rate of general score of HAMD.The clinical efficacy and safety were evalulated with Hamilton Depressive Scale（HAMD）.Results The effect rate was 70.59% in research group and 45.16% in control group.There was statistical difference in the two groups（χ^2=4.32,P〈0.05）.At the end of 4 week,HAMD scores were statistical different between research group and control group（t=2.61,P〈0.05）,at the end of 6 week,CGI scores were statistical different between the two groups（t=2.24,P〈0.05）,and as far as adverse effect,no statistical difference was found.Conclusion Escitalopram combined with Quetiapine can improve the effect in the treatment of treatment resistant depression.