凋亡抑制基因survivin在乳腺癌组织的表达及其意义

Expression and clinical significance of anti-apoptosis gene survivin in breast cancer tissues

目的观察凋亡抑制基因survivin在乳腺癌组织的表达及其与临床各参数的关系，探讨survivin基因在乳腺癌发生中的作用及其与乳腺癌预后的关系。方法采用Western blot方法检测survivin基因在50例乳腺癌组织、50例乳腺癌旁组织、20例正常乳腺组织标本中的蛋白表达。结果50例乳腺癌组织中38例survivin表达阳性，50例乳腺癌旁组织中11例survivin表达阳性，20例正常乳腺组织无survivin蛋白表达，survivin蛋白阳性表达与乳腺癌的腋窝淋巴结转移有关，而与PR、ER和Her-2及患者年龄无关。结论survivin在乳腺癌发生中起重要作用，是乳腺癌患者临床预后的重要参数之一。

Objective To investigate the expression of survivin, an anti-apoptosis gene, in breast cancer tissues and its relationship with clinical parameters of breast cancer patients. To investigate the role of survivin in oncogenesis of breast cancer and its relation with prognosis of breast cancer. Methods Western blot was conducted to detect survivin expression in cancerous tissues and adjacent tissues of 50 breast cancer patients. 20 normal breast tissue samples were used as control. Results Survivin was expressed in 38 of the 50 breast cancer tissues （76.0%） and in 11 of 50 breast adjacent normal tissues （22.0%） while no expression was found in normal tissues. The positive protein expression of survivin was related to axillary lymph node metastasis of breast cancer while it was not related to expression of PR, ER, Her-2 or ages of patients. Conclusion Survivin may play a role in breast tumorigenesis and is an important predictive parameter in breast cancer patients.