过敏性紫癜复发与幽门螺杆菌感染的关系

Relationship between hench-schonlein purpura recurrence and helicobacter pylori infection

目的探讨儿童过敏性紫癜复发与幽门螺杆菌感染(Helicobacter pylori,Hp)的关系。方法根据过敏性紫癜是否反复发作,将76例过敏性紫癜患儿分为观察组和对照组,做13C-尿素呼气试验,检测有无Hp感染。结果两组患者Hp阳性者总例数比较,差异具有统计学意义(P<0.01),两组患者伴消化道症状者Hp阳性例数比较,差异具有统计学意义(P<0.05),两组患者不伴消化道症状者Hp阳性例数比较,差异无统计学意义(P>0.05)。结论 Hp感染可能是过敏性紫癜发病的诱发因素之一,对反复发作或伴明显胃肠道症状的过敏性紫癜患者可考虑进行Hp检测,及时发现和处理Hp感染,防止过敏性紫癜复发。

Objective To explore the relationship of Henoch-Schonlein purpura recurrence and Helicobacter pylori infection.Methods According to whether the Henoch-Schonlein purpura repeated attacks,the 76 cases of Henoch-Schonlein purpura patients were divided into observation group and control group,conduct 13C-substrate urea expiratory to test whether Helicobacter pylori infection.Results There was significant difference between the 2 groups of all Hp-positive patients（P0.01）,there was significant difference between the 2 groups of Hp-positive patients with gastrointestinal symptoms（P0.05）,there was not significant difference between the 2 groups of Hp-positive patients without gastrointestinal symptoms（P0.05）.Conclusions Helicobacter pylori infection may be one of triggering events which caused henoch-schonlein purpura recurring.Helicobacter pylori examined may be considered to henoch-schonlein purpura patients accompanied by severe abdominal symptoms and relapse patients.Hp eradication therapy may relieve abdominal pain and prevent recurring for Hp-positive patients.