深圳市罗湖区2007—2009年疑似预防接种异常反应病例分析

Analysis on the Cases of Adverse Events Following Immunization During 2007 to 2009 in Luohu District

目的分析深圳市罗湖区预防接种异常反应(AEFI)病例发生特征,评价AEFI监测系统运转情况,提供国家扩大使用疫苗的反应性和安全性的数据。方法通过中国免疫规划监测信息管理系统和儿童预防接种信息管理系统,收集全区报告的2007—2009年AEFI个案,采用描述性方法对相关指标进行流行病学分析。结果 2007—2009年共发生AEFI病例130例,2007年、2008年AEFI报告发生率为1.00/10万～1.05/10万,2009年AEFI发生率大幅度上升,达到12.66/10万。在发生的AEFI分类诊断中,一般反应占47.69%,异常反应占45.38%,其他<7.00%。临床损害前3位为发热/红肿/硬结、无菌性脓肿和过敏反应。结论国家免疫规划疫苗的安全性和预防接种服务质量良好,但AEFI监测工作仍需进一步规范。

OBJECTIVE To analyze the characteristics of adverse Events Following Immunization（AEFI）in Luohu District,Shenzhen City,and to evaluate the implementation of AEFI surveillance system,provide scientific evidence about safety and reactivity of the vaccine for national expanded immunization.METHOD Descriptive epidemiology was adopted to analyze the cases of AEFI in Luohu from 2007 to 2009,which were collected by the China immunization monitoring information management system and Childhood Immunization Information Management System.RESULTS The reported AEFI cases were 130 from 2007 to 2009.And the reported incidence rate of AEFI cases was 1.00/100 000～1.05/100 000 in 2007 to 2008,which substantially increased to 12.66/100 000 in 2009.In the classification of AEFI cases,47.69% cases were common,minor reactions,45.38% were rare,serious reactions and others were〈7.00%.Fever/flare/induration,aseptic abscess and Anaphylaxis were the most common clinical diagnosises.CONCLUSIONS Safety of NIP vaccines and the quality of immunization services were satisfied,but it still needs to be strengthened.