CBS催化合成β-受体激动剂关键中间体——手性α-卤代仲醇

Catalytic synthesis of key intermediates of β-receptor agonist ------chiral α-halo secondary alcohols by CBS catalysts

用CBS催化剂中的R/S-α,α-二苯基脯氨醇为催化剂不对称还原α-卤代苯乙酮衍生物,得到系列手性α-卤代仲醇——β-受体激动剂关键中间体,反应具有较好的收率,产物光学纯度高。

A series of chiral α-halo secondary alcohols, the key intermediates of β-receptor agonists, was obtained via asymmetric reduction of α-halo-acetophenone derivatives catalyzed by Corey-Bakshi-Shibata （CBS） catalyst （R/S）-α,α-diphenyl-2-pyrrolidinemethanol and their yield and optical purity were better.