期刊文献+

胱抑素C在糖尿病性肾病中的探讨 被引量:1

下载PDF
导出
摘要 目的:检测血清胱抑素C(Cys-C)浓度并与血清肌酐(Cr)、血清尿素氮(BUN)、血β2微球类蛋白(β2-MG)进行比较,从而评价血清胱抑素在糖尿病患者的早期诊断的价值.方法:应用颗粒免疫比浊法测定177例糖尿病伴有肾脏损害患者(肾功能正常45例,轻度异常48例,中度异常32例,重度异常52例)的血清Cys-C浓度,并与血清BUN、血清Cr、血β2-MG进行比较.结果:糖尿病肾病各型患者血清CysC与β2-MG水平升高,与对照组差异有统计学意义(P〈0.05),糖尿病肾功能中、重度异常组Scr水平明显高于对照组 (P〈0.05).血清Cys-C浓度与β2-MG相关系数(r =0.8267,P〈0.01),差异有显着性.结论:血清Cys-C浓度是一个灵敏的肾小球滤过率的标志物,能用于评价糖尿病患者的肾功能状况. Purpose: To test Serum cystatin C (Cys--C) concentration and compare with serum creatinine (Cr), blood urea nitrogen (BUN), serum β2--Ball protein (β2--MG) ,in order to evaluate the value of serum cystatin in the early diagnosis. Methods: To apply the Particles lmmunoturbidimetry to determine concentration of serum Cys--C of 177 cases of diabetes associated with kidney damage(45 patients with normal renal function, mild abnormalities in 48 casee,moderately abnormal in 32 cases, 52 cases of severe abnormalities) ,and compare with serum BUN, serum Cr, serum β2--MG. Results: Levels of serum Cys--C and β2--MG of Diabetic nephropathy in mild, moderate and severe levels tended to increase, significantly higher than the cantrol group (P〈0.05), but levels of Scr was significantly higher than the control group (P〈0.05) only in diabetic renal and severe abnormal group. Serum Cys--C concentration and β2--MG correlation coefficient (r = 0. 8267, P 〈0.01), the difference was significant. Conclusion:Serum Cys--C concentration is a sensitive marker of glomerular filtration rate and can be used to evaluate the status of renal function in diabetic patients.
作者 周华胜
出处 《医学信息(下旬刊)》 2011年第6期290-290,共1页 Medical information
关键词 糖尿病性肾病 Systatin C 肾小球滤过率 内生肌酐清除率 肌酐 Diabetic nephropathy Systatin C Glomerular filtration rate Endogenous creatinine clearance rate Creatinine
  • 相关文献

参考文献8

二级参考文献29

  • 1钟爱民,刘燕鸣,陈红,魏小昌,李赟,刘精东.血清胱抑素-C是反映肾小球滤过功能的敏感指标[J].临床肾脏病杂志,2004,4(4):166-167. 被引量:22
  • 2张贺平,王东红,李洪娟,王莹,李忠信.尿胱抑素C的变化评估肾损害患者肾小管损伤的临床意义[J].江西医学检验,2005,23(5):421-423. 被引量:21
  • 3王鲁雁,孙宁玲,常玲,刘喜荣.高血压糖尿病患者尿微量白蛋白与动脉弹性之间的关系[J].中华心血管病杂志,2006,34(5):387-390. 被引量:36
  • 4谢群芳,王叶舟,戴文森.血清胱抑素C清除值估测肾小球滤过率的临床评价[J].中国误诊学杂志,2007,7(9):1969-1970. 被引量:56
  • 5Simonsen O, Grubb A, Thysell H. The blood serum concentration of Cystatin C (gamma - trace) as a measure of the glomerular filtration rate [J ]. Scand J Clin Lab Invest, 1985,45(2) :97 - 101.
  • 6Simonsen O, Grubb A, Thysll H. The blood serum concentration of cystatin C (γ-trace) as a meaures of the glomerular filtration rate. Scand J Clin Invest, 1985, 45: 97~102.
  • 7Newman DJ, Thakkar H, Edwards RG, et al. Serum cystatin C measured by automated immunoassy: A more sensitive marker of changes in GFR than serum creatinine. Kidney Internation,1995, 47: 312~394.
  • 8Kos J, Stabuc B, Cimerman N, et al. Serum cystatin C: A new marker of glomerular filtration rate, is increased during malignant progression. Clin Chem, 1998, 44: 2556~2557.
  • 9Stefan HK, Sillce T, Frank P, et al. Cystatin C: Efficacy as screening test for reduced glomerular filtration rate. Am J Nephro, 2000, 20(2): 97~102.
  • 10Coll E, Wirtz O, Heli Ⅰ, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early impairment. Am J Kidney Dis, 2000, 36: 29~34.

共引文献107

同被引文献5

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部