腹腔镜手术治疗异位妊娠的临床对照观察

The Clinical Contrastive Observation on the Effects of Laparoscopic Surgery in Ectopic Pregnancy

目的:探讨腹腔镜手术治疗异位妊娠的疗效。方法:选取2008年1月～2010年10月于本院进行手术的88例异位妊娠患者为研究对象,将其随机分为对照组(开腹手术组)44例和观察组(腹腔镜手术组)44例,后将两组患者的手术时间、出血量、排气时间、并发症发生率及手术前和手术后1d及5d的血清IL-6、IL-8及TNF-α、CRP水平和外周血T淋巴细胞亚群进行统计及比较。结果:观察组的手术时间及排气时间均短于对照组,出血量少于对照组,并发症发生率低于对照组,两组患者手术前和手术后1d及5d的血清IL-6、IL-8及TNF-α、CRP水平均呈现先升后降的趋势,而外周血T淋巴细胞亚群除CD8+外均呈现先降后升的趋势,且观察组变化幅度较对照组,P均<0.0.5,均有显著性差异。结论:腹腔镜手术治疗异位妊娠的疗效较佳,且其引起的机体的炎症性反应较小,值得临床进一步研究及推广应用。

Objective：To study the effects of laparoscopic surgery in ectopic pregnancy.Methods：88 patients with ectopic pregnancy in our hospital from January 2008 to October 2010 were selected as research onject,and they were randomly divided into control group（open surgery group）44 cases and observation group（laparoscopic surgery group）44 cases,then the operation time,blood loss,exhaust time,incidence of complications and serum IL-6,IL-8,RP, TNF-α and peripheral blood T lymphocyte subsets before and after the surgery at first and fifth day were all analyzed and compared.Results：The operation time and exhaust time of observation group were both shorter than those of control group,the blood loss of observation group was less than that of control group,incidence of complications was lower than that of control group,serum IL-6,IL-8 and CRP, TNF-α before and after the surgery at first and fifth day of the two groups increased first and decreased afterwards, peripheral blood T lymphocyte subsets except CD8＋ decreased first and increased afterwards all P（0.05,there were all significant significant differences.Conclusion：The effects of laparoscopic surgery in ectopic pregnancy is better, and the influence for the body is smaller, so laparoscopic surgery is worthy of further studying and popularization and application.